摘要
目的分析1例成人流行性乙型脑炎(Japanese encephalitis,JE)患者的临床、实验室检查及影像学特点,了解成人JE与儿童JE临床特征的差异性,并探讨其病原学检测方法。方法回顾性分析1例需入院治疗的成人JE患者的临床、实验室检查及影像学资料,复习相关文献资料。结果JE患者临床症状无特异性,主要表现为发热、意识及认知障碍、抽搐及脑膜刺激征。其主要检测指标是急性期脑脊液和血清标本中乙型脑炎病毒(Japanese encephalitisvirus,JEV)IgM抗体。颅脑MRI是JE重要的辅助检查手段,常见受累部位为丘脑、基底节和脑皮质。结论JE临床表现无特异性,诊断上需同时结合流行病学资料、实验室检查及特异性抗体检测明确,丘脑损害是最常见的影像学改变。
Objective The features of clinical,laboratory and radiologic examinations of an adult patient with Japanese encephalitis(JE)were analyzed to understand the differences in clinical characteristics between adult and children patients,and to investigate the method of etiological tests.Methods The clinical,laboratory tests and radiographic data of an adult case with JE requiring hospitalization were analyzed retrospectively and the related literature was reviewed.Results The clinical presentation of patients with JE was nonspecific,the patient presented with fever,consciousness and cognitive impairment,convulsion and meningeal irritation.Its main test indicator is IgM antibody of Japanese encephalitis virus(JEV)in acute cerebrospinal fluid and serum specimens.Craniocerebral MRI is an important auxiliary examination for JE,the common sites involved are thalamus,basal ganglia and cerebral cortex,of which thalamus is almost 100%affected.Conclusions The clinical presentation of patients with JE was nonspecific.Clear diagnosis should be accompanied by the combination of epidemiology,laboratory tests and specific antibodies detection.Neural damages commonly occur in thalamus.
作者
刘策
田地
赵海清
涂银萍
Liu Ce;Tian Di;Zhao Haiqing;Tu Yinpin(Department of Infectious Disease,Beijing Chuiyangliu Hospital,Beijing 100022,China;Department of Neurology,Beijing Chuiyangliu Hospital,Beijing 100022,China;Department of Radiology,Beijing Chuiyangliu Hospital,Beijing 100022,China)
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
2019年第5期536-540,共5页
Chinese Journal of Experimental and Clinical Virology
