摘要
代谢重编程是细胞对于环境改变所作出的反应,如细胞的活化、增殖与分化,其中涉及代谢相关酶、代谢产物以及代谢途径等方面的变化。脓毒症相关免疫细胞在对炎症信号作出反应后,会经历代谢重编程,这不仅满足了生物能量和生物合成的需求,还以一种高度特异性的方式决定了细胞的命运和功能。本文针对巨噬细胞、T淋巴细胞、树突细胞、中性粒细胞4种脓毒症相关免疫细胞的糖酵解、三羧酸循环、氧化磷酸化等糖代谢途径的变化进行分析总结,为将来的研究和代谢疗法提供可行性。
Metabolic reprogramming is the response of cells to environmental changes,such as cell activation,proliferation and differentiation,which involves changes in metabolism-related enzymes,metabolites and metabolic pathways.Sepsis-associated immune cells undergo metabolic reprogramming in response to inflammatory signals,which not only provides biological energy and biosynthesis requirements,but also determines cell fate and function in a highly specific way.In this paper,the changes in glycolysis,tricarboxylic acid cycle,oxidative phosphorylation and other glucose metabolism pathways of macrophages,T lymphocytes,dendritic cells,neutrophils and other sepsis related immune cells are described,so as to provide feasibility for future research and metabolic therapy.
作者
王丹阳
刘美云
吕欣
Wang Danyang;Liu Meiyun;Lyu Xin(Department of Anesthesiology,China-Japan Friendship Hospital of Jilin University,Changchun 130033,Jilin,China;Department of Anesthesiology,Shanghai Pulmonary Hospital of Tongji University,Shanghai 200433,China)
出处
《中华危重病急救医学》
CAS
CSCD
北大核心
2019年第9期1167-1169,共3页
Chinese Critical Care Medicine
基金
国家自然科学基金(81671947,81871601)。
关键词
脓毒症
免疫细胞
代谢重编程
炎症反应
Sepsis
Immune cell
Metabolic reprogramming
Inflammatory response
