摘要
目的探讨老年肿瘤患者检测T淋巴细胞亚群的临床意义。方法以2019年1月至4月扬州市江都人民医院收治的82例中老年恶性肿瘤患者为研究对象,抽取患者肘静脉血液样本,测定T淋巴细胞亚群CD3、CD4、CD8细胞的绝对计数,计算CD4/CD8值,观察指标水平。结果82例老年肿瘤患者CD3、CD4细胞绝对计数值均低于正常参考值下线,指标降低率100%,平均指标值分别为450.74和241.34个/μL。72例CD8细胞绝对计数值低于正常参考值下线,指标降低率87.80%,平均指标值199.82个/μL。62例患者CD4/CD8正常,占比75.61%,平均指标值1.45亦在正常水平范围。不同肿瘤类型患者CD3、CD4、CD8、CD4/CD8平均水平无统计学差异(P>0.05)。结论老年恶性肿瘤患者多伴不同程度CD3、CD4、CD8与CD4/CD8异常,特别是CD3和CD4,灵敏度高,临床对此进行检测在识别和诊断老年恶性肿瘤具有指导价值。
Objective To investigate the clinical significance of detecting T lymphocyte subsets in elderly cancer patients.Methods Eighty-two middle-aged and elderly patients with malignant tumors admitted to our hospital from January 2019 to April were selected as the research objects.The blood samples of elbow vein were collected.The absolute counts of T lymphocyte subsets CD3,CD4 and CD8 were measured.The CD4/CD8 values were calculated and the index levels were observed.Results The absolute counts of CD3 and CD4 cells in 82 elderly patients with cancer were lower than the normal reference values.The reduction rate of CD3 and CD4 cells was 100%.The average values of CD3 and CD4 cells were 450.74 and 241.34/μL,respectively.The absolute count of CD8 cells in 72 cases was lower than the normal reference value.The index reduction rate was 87.80%.The average index value was 199.82/μL.CD4/CD8 was normal in 62 patients,accounting for 75.61%.The average index value was 1.45 in the normal range.The average levels of CD3,CD4,CD8 and CD4/CD8 in patients with different types of tumors were not significantly different(P>0.05).Conclusion The elderly patients with malignant tumors often have abnormal CD3,CD4,CD8 and CD4/CD8 in different degrees,especially CD3 and CD4,which have high sensitivity.Clinical detection of CD3 and CD4 has guiding value in identifying and diagnosing malignant tumors in the elderly.
作者
许晖
XU Hui(Medical College of Yangzhou University(Yangzhou Jiangdu People's Hospital),Yangzhou,Jiangsu 225200,China)
出处
《大医生》
2019年第11期24-25,共2页
Doctor
关键词
中老年
恶性肿瘤
血液检测
T淋巴细胞亚群
临床意义
middle and old age
malignant tumors
blood test
T lymphocyte subsets
clinical significance
