摘要
目的研究探讨妊娠期血清铁(SI)、铁蛋白(SF)、可溶性转铁蛋白受体(sTfR)水平与妊娠期妇女贫血的关系。方法选取2016年1月至2018年1月惠州市中心人民医院产科接受产前检查的150例妊娠期贫血患者作为研究对象。将这150例妊娠期贫血患者纳入贫血组,另选同期在惠州市中心人民医院进行产检的非贫血妊娠期妇女150例作为对照组,采用放射免疫分析法检测两组受试者的SI、SF、sTfR水平,采用全自动生化分析仪检测两组受试者的血红蛋白(Hb)、红细胞计数(RBC),并进行组间比较。并对不同孕期的贫血组患者的SI、SF、sTfR、Hb、RBC等指标水平进行统计对比。最后,采用Pearson相关性检验对贫血组SI、SF、sTfR与Hb、RBC相关性进行分析探讨。结果贫血组患者的SI、SF、Hb、RBC水平均低于对照组,sTfR水平高于对照组,组间比较差异具有统计学意义(P<0.0)。在贫血组患者中,孕早期、孕中期、孕晚期患者随着孕期的延长,SI、SF、Hb、RBC水平呈降低趋势,而sTfR水平呈升高趋势,各组间比较差异有统计学意义(P<0.0)。经Pearson相关性检验分析,SI、SF与Hb、RBC呈正相关性,sTfR与Hb、RBC呈负相关性。结论妊娠期贫血妇女的血清铁、铁蛋白水平明显降低,可溶性转铁蛋白受体水平升高,并与患者所处的孕期有关,提示上述指标可能参与到妊娠期贫血的发生发展过程,可作为妊娠期贫血诊断的标志物。
Objective To investigate the relationship between serum iron(SI),ferritin(SF)and soluble transferrin receptor(sTfR)levels during pregnancy and anemia in pregnant women.Methods A total of 150 anaemia patients who received prenatal examination in our department of obstetrics from January 2016 to January 2018 were enrolled in the anemia group.150 women with non-anemic pregnancy during the same period in our hospital were enrolled into the control group.The levels of SI,SF and sTfR in the two groups were detected by radioimmunoassay.The hemoglobin(Hb)and red blood cell count(RBC)of the two groups were detected by automatic biochemical analyzer.The levels of SI,SF,sTfR,Hb,RBC and other indicators in the anemia group of different trimesters of pregnancy were statistically compared.Finally,Pearson correlation test was used to analyze the correlation between SI,SF,sTfR,Hb and RBC in anemia group.Results The levels of SI,SF,Hb and RBC in the anemia group were lower than those in the control group,and the sTfR level was higher than that in the control group,all with statistically significant differences(P<0.05).In the anemia group,the levels of SI,SF,Hb,and RBC decreased in the first trimester,the second trimester,and the third trimester,and the sTfR levels increased,all with statistically significant differences(P<0.05).According to the Pearson correlation test,SI and SF were positively correlated with Hb and RBC,and sTfR was negatively correlated with Hb and RBC.Conclusions Serum iron and ferritin levels are significantly decreased in pregnant women with anemia,and soluble transferrin receptor levels are elevated,which is related to the pregnancy trimesters of the patients,suggesting that the above indicators may be involved in the development and progression of anemia during pregnancy,which can serve as a marker for the diagnosis of anemia during pregnancy.
作者
陈翠娜
黄沛嫔
巫华玉
CHEN Cuina;HUANG Peipin;WU Huayu(Department of Obstetrics,Huizhou Central People′s Hospital,Huizhou 516001,Guangdong,China)
出处
《中国性科学》
2019年第11期49-52,共4页
Chinese Journal of Human Sexuality
关键词
妊娠期贫血
血清铁
铁蛋白
可溶性转铁蛋白受体
血红蛋白
红细胞计数
Anemia during pregnancy
Serum iron(SI)
Ferritin(SF)
Soluble transferrin receptor(sTfR)
Hemoglobin(Hb)
Red blood cell count(RBC)
