摘要
目的 系统评价PRKAA1rs13361707基因多态性与中国人群胃癌易感性之间的关系。方法 全面检索国内外数据库,搜集有关中国人群PRKAA1rs13361707基因多态性与胃癌关系的病例-对照研究,采用Stata12.0软件进行Meta分析。结果 共纳入10篇文献,Meta结果显示,基因型CC、等位基因C增加中国人群罹患胃癌风险(CC vs. TT:OR=1.90,95%CI:1.60~2.27,P <0.01;CC vs. CT+TT:OR=1.52,95%CI:1.36~1.70,P <0.01;C vs. T:OR=1.38,95%CI:1.26~1.51,P <0.01)。结论 PRKAA1rs13361707基因多态性与中国人群胃癌易感性相关。
Objective To systematically evaluate the association between PRKAA1 rs13361707 polymorphism and susceptibility of gastric cancer(GC)in Chinese population.Methods All case-control studies related to PRKAA1 rs13361707 polymorphism and GC risk in Chinese population were searched from databases at home and abroad.The meta-analysis was performed using Stata 12.0 software.Results A total of ten studies were finally included.Meta-analysis showed that CC genotype and C-allele genotype increased the susceptibility of GC in Chinese population(CC vs.TT:OR=1.90,95%CI:1.60~2.27,P<0.01;CC vs.CT+TT:OR=1.52,95%CI:1.36~1.70,P<0.01;C vs.T:OR=1.38,95%CI:1.26~1.51,P<0.01).Conclusion PRKAA1 rs13361707 polymorphism had a significant relationship with GC risk in Chinese population.
作者
刘佳
葛宽雪
林加湘
刘克伟
李蕾
喻群力
LIU Jia;GE Kuanxue;LIN Jiaxiang;LIU Kewei;LI Lei;YU Qunli(Department of Gastroenterology,Jiangdu People’s Hospital of Yangzhou City,Yangzhou 225200,Jiangsu Province,China)
出处
《大医生》
2019年第3期40-42,共3页
Doctor
