摘要
目的研究孕妇产前诊断中唐氏筛查的临床意义。方法选取江苏省溧阳市妇幼保健院2016年7月至2018年12月接收的8900例产前检查孕妇,对所有孕妇进行血清甲胎蛋白和游离β绒毛膜促性腺激素水平检测,对风险较高的孕妇进行遗传咨询和产前诊断。结果8900例孕妇筛查出高风险孕妇580例,阳性率6.51%,包括唐氏综合征高风险孕妇359例,其中302例接受产前诊断,发现胎儿染色体异常11例,异常检出率3.64%,包括唐氏综合征7例,18三体综合征1例。结论对孕妇进行产前唐氏筛查对于诊断胎儿的健康状况意义重大,对于优生优育具有较高的临床价值。
Objective To study the clinical significance of Down's screening in prenatal diagnosis of pregnant women.Methods Totally 8900 pregnant women received prenatal screening in our hospital were selected from July 2016 to December 2018.Serum alpha-fetoprotein and freeβ-chorionic gonadotropin levels were detected in all pregnant women,and genetic counseling and prenatal diagnosis were carried out for pregnant women at higher risk.Results Totally 580 high-risk pregnant women were screened out in 8900 pregnant women,the positive rate was 6.51%,including 359 high-risk pregnant women with Down's syndrome.Among them,302 high-risk pregnant women received prenatal diagnosis,and 11 cases of fetal chromosomal abnormalities were found,the detection rate was 3.64%,including 7 cases of Down's syndrome and 1 case of chromosome 18-trisomy syndrome.Conclusion Prenatal Down's screening for pregnant women is of great significance for the diagnosis of fetal health,and has high clinical value for eugenics and fertility.
作者
曹爱邡
CAO Aifang(Clinical Laboratory,Maternity Care Hospital of Liyang City,Liyang,Jiangsu 213300,China)
出处
《大医生》
2019年第10期58-59,共2页
Doctor
关键词
孕妇
产前检查
唐氏筛查
pregnant women
prenatal examination
down's screening
