摘要
目的探究雷火炙对于子宫内膜异位症的临床治疗效果情况。方法选取2016年9月至2018年2月在海口市中医医院进行治疗的子宫内膜异位症患者71例作为研究对象,将这些患者随机分为两组,对照组35例采用药物治疗,观察组36例在对照组的基础上采用雷火灸方式进行治疗,观察比较两组患者治疗前后盆腔疼痛改善情况、血清白细胞介素-6(IL-6)、血管内皮生长因子(VEGF)、血清TNF-α含量、血清糖类抗原125(CA125)含量和抗转铁蛋白抗体(TFAb)阳性比例变化情况。结果观察组患者治疗1个月后疼痛评分(5.35±1.27)分、2个月后(3.46±1.45)分、3个月后(2.65±1.09)分;IL-6(17.15±6.07)ng/L、VEGF(72.68±4.23)ng/L、TNF-α(5.36±1.78)ng/L、CA125(17.68±3.36)U/ml、TFAb阳性2例(5.56%)、维生素D(17.57±2.38)μg/L优于对照组患者的1个月后疼痛评分(6.53±1.35)分、2个月后(5.26±1.63)分、3个月后(4.43±1.27)分,IL-6(23.57±6.34)ng/L、VEGF(95.53±5.37)ng/L、TNF-α(7.67±1.38)ng/L、CA125 (23.83±4.27)、TFAb阳性9例(25.71%)、维生素D(13.26±2.13)μg/L,差异有统计学意义(P<0.05)。结论雷火炙可以有效改善子宫内膜异位症患者的盆腔疼痛情况和临床效果,减少血清IL-6、VEGF、TNF-α、CA125含量和血清TFAb阳性比例,提高维生素D水平,增强患者机体免疫功能。
Objective To observe the therapeutic effect of Leihuozhi on endometriosis. Methods 71 patients with endometriosis who were treated in Haikou Hospital of Traditional Chinese Medicine from September 2016 to February 2018 were enrolled in our study and randomly divided into control group(35 cases) and observation group(36 cases).Patients in control group were treated with routine medicine, while patients in the observation group were treated with Leihuozhi along with routine medicine.Changes in pelvic pain, serum levels of interleukin-6(IL-6), vascular endothelial growth factor(VEGF), TNF-α, carbohydrate antigen 125(CA125) and anti-transferrin antibody(TFAb) positive ratio were compared after the treatment between the two groups. Results The scores of pelvic pain of patients in the observation group at one month, two month and three month after the treatment were significantly lower compared to those in control group(5.35±1.27 vs 6.53±1.35;3.46±1.45 vs 5.26±1.63;2.65±1.09 vs 4.43±1.27;P<0.05).Meanwhile, the serum levels of IL-6, VEGF, TNF-a, CA125 as well as the TFAb positive ratio of patients in the observation group were lower than those in the control group(17.15±6.07 vs 23.57±6.34) ng/L;(72.68±4.23 vs 95.53±5.37) ng/L;(5.36±1.78 vs 7.67±1.38) ng/L;(17.68±3.36 vs 23.83±4.27) U/ml;5.56% vs 25.71%, the differences were statistically significant(P<0.05), while, the serum level of vitamin D was higher in the observation group than that in control group(17.57±2.38 vs 13.26±2.13) ng/L(P<0.05). Conclusions Leihuozhi can effectively relieve the pelvic pain of patients with endometriosis,reduce serum levels of IL-6,VEGF,TNF-α,CA125 and the TFAb positive ratio,thereby improve the overall body immune function.
作者
陈元花
裴雄越
王金香
张娇珍
黄勇
CHEN Yuan-hua;PEI Xiong-yue;WANG Jin-xiang;ZHANG Jiao-zhen;HUANG Yong(Department of obstetrics and gynecology,Haikou Hospital of traditional Chinese medicine,Haikou,Hainan 570000,China)
出处
《中国预防医学杂志》
CAS
CSCD
2019年第9期831-834,共4页
Chinese Preventive Medicine
基金
海南省重点研发计划项目(ZDYF2017109)
