摘要
细胞焦亡是细胞感染时由炎症小体介导,以裂解细胞为特点的程序性死亡形式。其激活途径分为依赖半胱氨酸蛋白酶-1或半胱氨酸蛋白酶-4/5/11活化的经典与非经典途径。目前的研究表明细胞焦亡过程中主要效应蛋白是具有膜成孔活性的gasdermin(也作GSDM)家族成员。因此,细胞焦亡也被称为gasdermin介导的程序性坏死。当宿主受到感染时,细胞焦亡与宿主自身其他免疫防御机制存在互相调节机制,保证宿主在清除感染的同时降低自身损伤程度。本文笔者将从研究最为广泛的GSDMD在细胞焦亡途径中的作用机制、细胞焦亡在感染性疾病中的研究进展以及细胞焦亡与其他程序性死亡在感染性疾病中的相互作用这三个方面作系统叙述,期望为今后研究如何通过细胞焦亡途径治疗感染性疾病提供理论基础。
Pyroptosis is a form of inflammasome-mediated cell programmed death which exhibits cell lysis upon infection.The activation pathway is divided into canonical pathway via caspase-1 activation and noncanonical pathway via caspase-4/5/11 activation.Recent studies have shown that main effector proteins in pyroptosis are gasdermin(also known as GSDM)family members bearing a novel membrane pore-forming activity.Therefore,pyroptosis is also defined as a cell programmed death mediated by gasdermin.There is cross-regulation between pyroptosis and other immune defense mechanisms so that the host clears infection and relieves damage extent during infection.This review focuses on the function of GSDMD in pyroptosis,research progress of pyroptosis in infectious diseases,and the interaction between pyroptosis and other cell programmed death upon infection.We hope that this review can provide a theoretical basis for the treatment of infectious diseases by targeting pyroptosis.
作者
刘瑞卿
李胜玉
申艳娜
Ruiqing Liu;Shengyu Li;Yanna Shen(School of Laboratory Medicine,School of Medical Technology,Tianjin Medical University,Tianjin 300203,China)
出处
《微生物学报》
CAS
CSCD
北大核心
2019年第11期2083-2093,共11页
Acta Microbiologica Sinica
基金
国家自然科学基金(81772252)~~
