摘要
溃疡性结肠炎是一种以腹泻、腹痛、脓血便为主要表现的肠道免疫炎症性疾病,由巨噬细胞超活化所导致的非可控性炎症是溃疡性结肠炎发病和逐渐恶化的重要原因,因此抑制巨噬细胞超活化是治疗溃疡性结肠炎的有效途径之一。Notch信号通路参与了调节巨噬细胞的免疫应答并促进炎症反应,NF-κB信号通路是参与炎症反应的“明星通路”,NLRP3炎症小体参与了巨噬细胞的活化过程,在已有的免疫炎症性疾病中Notch,NF-κB,NLRP3炎症小体三者之间构成了上下游的信号转导通路,Notch可通过NF-κB/NLRP3炎症小体信号通路调节巨噬细胞的活化。
Ulcerative colitis is an intestinal infl ammatory disease characterized by diarrhea,abdominal pain and purulent stool.Uncontrolled infl ammation caused by macrophage hyper-activation is an important cause of ulcerative colitis.Th erefore,inhibiting macrophage hyper-activation is an eff ective way to treat ulcerative colitis.Notch signaling pathway is involved in regulating the immune response of macrophages and promoting inflammation.NF-κB signaling pathway is the“star pathway”involved in inflammation.NLRP3 inflammatory body is involved in the activation of macrophages.Notch,NF-κB and NLRP3 inflammatory bodies constitute the upstream and downstream signal pathways in the existing immune inflammatory diseases.Notch signal pathway can regulate the activation of macrophage via NF-κB/NLRP3 inflammatory body signaling pathway.
作者
闫曙光
许小凡
李倩
惠毅
李京涛
魏海梁
YAN Shuguang;XU Xiaofan;LI Qian;HUI Yi;LI Jingtao;WEI Hailiang(College of Basic Medicine,Shanxi University of Chinese Medicine,Xianyang Shanxi 712046;Department of Hepatology,Affi liated Hospital,Shanxi University of Chinese Medicine,Xianyang Shanxi 712000;Departments of General Surgery,Affi liated Hospital,Shanxi University of Chinese Medicine,Xianyang Shanxi 712000,China)
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2019年第10期1174-1178,共5页
Journal of Central South University ：Medical Science
基金
国家自然科学基金(81403320,81873233)
陕西中医药大学学科创新团队建设项目(2019-YL05)~~
