摘要
微生物在抑郁症、自闭症等心理应激性疾病中发挥重要作用,且能在母-子间传递。在母子应激传递中,肠黏膜屏障和血脑屏障通透性的增加,使肠道微生物通过肠-脑轴和心理应激关联起来,而胎盘屏障通透性的增加,使母子肠道微生物传递在胎儿发育期发挥作用,从而影响子代情志和认知发育。心理应激对屏障通透性的影响可能通过两方面发挥作用:(1)神经体液因素;(2)菌群失调。基于屏障通透性的改变,肠道微生物参与了HPA轴激活及母子间应激传递过程的各个环节,可能是干扰胎盘屏障通透性改变的始发因素。探讨微生物在母子心理应激传递中的作用,可通过改善肠道微生物,将疾病消灭在起始阶段,对优生优育、减少成年期疾病的发生以及提高家庭幸福指数均具有重要意义。
Microbiota plays an important role in psychological stress diseases such as depression,autism and so on,and can be transferred between mother and offspring.In the mother-offspring stress transfer,increased permeability of the intestinal mucosa barrier and blood brain barrier makes a connection between the gut-brain axis and the psychological stress by gut microbiota,while increased permeability of placental barrier makes gut microbiota transfer between mother and offspring play apart in fetal development,thus affects the emotional and cognitive development of offspring.The effect of psychological stress on permeability may play a role in two aspects:one is the neurohumoral factors,and the other is microbial dysbiosis.Based on the change of barrier permeability,gut microbiota participates in all aspects of HPA axis activation and the process of stress transfer between mother and offspring,and it may be the initiator to disturb the permeability of the placental barrier.It is of important significance to investigate the role of microorganisms in maternal psychological stress transfer,which can improve the gut microbiota,eradicate the disease in the initial stage,reduce the incidence of adult diseases and improve family happiness index.
作者
李新民
杨丽萍
LI Xinmin;YANG Liping(School of Basic Medicine,He′nan University of Chinese Medicine,Zhengzhou,He′nan 450046,China)
出处
《中国微生态学杂志》
CAS
CSCD
2019年第10期1223-1226,共4页
Chinese Journal of Microecology
基金
国家自然科学基金面上项目(81373790)
关键词
微生物
屏障通透性
心理应激
母子传递
Microbiota
Barrier permeability
Psychological stress
Mother-offspring transfer
