摘要
目的:评价葛根芩连汤配合针刺治疗溃疡性结肠炎活动期大肠湿热证的临床疗效。方法:将纳入标准的120例患者,采用随机分配方法分为观察组和对照组各60例,研究中脱落8例,最终完成112例,观察组57例,对照组55例,对照组给予枯草杆菌二联活菌肠溶胶囊配合美沙拉嗪肠溶片,3月为1疗程;观察组给予经方葛根芩连汤配合针刺治疗,3月为1疗程。结果:两组患者治疗后腹泻、脓血便、腹痛、里急后重均较治疗前改善(P<0.05);且治疗后观察组均低于对照组(P<0.05);两组患者治疗后肠道症状、全身症状、情感能力、社会能力均较治疗前改善(P<0.05);且治疗后观察组均高于对照组(P<0.05);两组患者治疗后黏膜病变分级与治疗前比较均具有差异(P<0.05);治疗后观察组与对照组比较差异具有统计学意义(χ^2=9.426,P=0.041);两组治疗后血清IL-8、TNF-α水平均较治疗前降低(P<0.01);治疗后观察组均低于对照组;两组治疗前结肠镜下病变活动水平无显著性差异(t=0.584,P=0.608);治疗后观察组结肠镜下病变活动水平低于对照组(P<0.05)。结论:葛根芩连汤配合针刺能够明显改善溃疡性结肠炎活动期大肠湿热证的临床症状、提高生存质量、改善肠黏膜及降低血清炎性因子表达水平。
Objectives:To evaluate the clinical effect of classical prescription of Gegen Qinlian decoction combined with acupuncture for ulcerative colitis with large intestine damp-heat syndrome at active stage.Methods:120 cases patients was selected that accorded with the inclusion criteria was randomly divided into the experimental group and the control group,and each group had 60 cases patients.There were 8 cases of shedding in the study,112 cases were finally completed,including 57 cases in the experimental group and 55 cases in the control group.In the control group,bacillus subtilis enteric-coated capsules with live bacteria and mesalazine enteric-coated tablets were given and for a course of 3 months;the experimental group were given the classical prescription of Gegen Qinlian decoction combined with acupuncture treatment,3 months for a course of treatment.Results:Diarrhea,purulent blood stool,abdominal pain and tenesmus were all improved in both groups after treatment(P<0.05);after treatment,and the experimental group were lower than the control group(P<0.05).The intestinal symptoms,systemic symptoms,emotional ability and social ability of the patients in the two groups were all improved after treatment(P<0.05);after treatment,and the experimental group were all higher than those in the control group(P<0.05).There were differences in the grading of mucosal lesions between the two groups after treatment and before treatment(P<0.05).After treatment,the difference between the experimental group and the control group was statistically significant(χ^2=9.426,P=0.041).Serum TNF-αand IL-8 levels in both groups were lower after treatment than before treatment,and the differences were statistically significant(P<0.01).After treatment,the expression levels in the experimental group were lower than those in the control group.There was no significant difference in the activity level of lesions under colonoscopy between the two groups before treatment(t=0.584,P=0.608).After treatment,the activity level of colonoscopy in the ex
作者
乔峰
强文娟
高东
徐长青
QIAO Feng;QIANG Wenjuan;GAO Dong(Chinese Medicine Internal Medicine,Yulin Traditional Chinese Medicine Hospital in Shaanxi Province,Yulin 719000)
出处
《陕西中医》
2019年第11期1516-1519,共4页
Shaanxi Journal of Traditional Chinese Medicine
基金
陕西省中医药管理局资助项目(2017-LCMS034)
关键词
溃疡性结肠炎
大肠湿热证
活动期
葛根芩连汤
针刺
临床疗效
Ulcerative colitis
Large intestine damp-heat syndrome
Active stage
Gegen Qinlian decoction
Acupuncture
Clinical effect
