摘要
目的探讨神经生长因子与盐酸氟桂利嗪治疗高血压脑出血患者对促进神经功能恢复、脑血流动力学的影响。方法选取我院2016年1月~2018年2月收治的110例高血压脑出血患者,采用随机数字表法分为联合组和对照组,各55例,对照组给予常规治疗,联合组同时给予神经生长因子与盐酸氟桂利嗪治疗;比较两组治疗前后的神经功能缺损评分(NIHSS)、改良Rank量表(mRS)评分、血肿体积、日常生活活动能力(ADL)量表评分,血清神经元特异性烯醇化酶(NSE)、S100B蛋白、髓鞘碱性蛋白(MBP),大脑中动脉、前动脉及后动脉的平均血流速度。结果治疗后,联合组NIHSS评分、血肿体积均低于对照组,差异具有统计学意义(P<0.05);联合组血清NSE、S100B蛋白、MBP水平均低于对照组,差异具有统计学意义(P<0.05);联合组大脑中动脉、前动脉及后动脉的平均血流速度均高于对照组,差异具有统计学意义(P<0.05);治疗3个月后,联合组mRS评分低于对照组(P<0.05),ADL评分则高于对照组(P<0.05);联合组不良反应发生率为10.91%,高于对照组的5.45%,但差异无统计学意义(P>0.05)。结论神经生长因子联合盐酸氟桂利嗪治疗高血压脑出血,有利于患者血肿的迅速吸收、改善脑组织的供血,达到促进患者神经功能恢复的作用。
Objective To investigate the effects of nerve growth factor and flunarizine hydrochloride on the recovery of neurological function and cerebral hemodynamics in patients with hypertensive intracerebral hemorrhage.Methods A total of 110 patients with hypertensive cerebral hemorrhage admitted to our hospital from January 2016 to February 2018 were randomly divided into the combined group and the control group,55 cases in each group.The control group received conventional treatment.The combined group was treated with nerve growth factor and flunarizine hydrochloride.The neurological deficit score(NIHSS),modified Rank scale(mRS)score,hematoma volume,and activities of daily living were compared before and after treatment.Capacity(ADL)scale score,serum neuron specific enolase(NSE),S100B protein,myelin basic protein(MBP),mean blood flow velocity of the middle cerebral artery,anterior and posterior arteries.Results After treatment,the NIHSS score and hematoma volume of the combined group were lower than the control group,the difference was statistically significant(P<0.05).The serum NSE,S100B protein and MBP levels in the combined group were lower than the control group,the difference was statistically significant(P<0.05);the mean blood flow velocity of the middle cerebral artery,anterior artery and posterior artery of the combined group was higher than that of the control group,the difference was statistically significant(P<0.05);After 3 months of treatment,the mRS score of the combined group was lower than that of the control group(P<0.05),and the ADL score was higher than that of the control group(P<0.05).The incidence of adverse reactions in the combined group was 10.91%,which was higher than 5.45%of the control group.However,the difference was not statistically significant(P>0.05).Conclusion Nerve growth factor combined with flunarizine hydrochloride is effective in the treatment of hypertensive intracerebral hemorrhage,which is beneficial to the rapid absorption of hematoma and the improvement of blood supply to bra
作者
韩晋
陈淑媛
董瑞宾
石艳超
HAN Jin;CHEN Shu-yuan;DONG Rui-bin;SHI Yan-chao(Department of Neurology,Tianjin Port Hospital,Tianjin 300456,China)
出处
《医学信息》
2019年第21期81-84,共4页
Journal of Medical Information
关键词
神经生长因子
盐酸氟桂利嗪
高血压脑出血
血流动力学
Nerve growth factor
Flunarizine hydrochloride
Hypertensive intracerebral hemorrhage
Hemodynamics
