摘要
以苯佐卡因为原料,通过微通道反应器,使苯佐卡因与不同的溴代衍生物发生取代反应,得到了一系列结构新颖的苯佐卡因衍生物,研究了反应条件对单取代和双取代反应的影响,最后对得到的衍生物进行初步生物活性测试,发现部分化合物对金黄色葡萄球菌其有一定的抗菌活性.
With benzocaine as starting material,a series of novel brominated derivatives were synthesized via substitution reaction in the micro-channel reactor.The effect of reaction condition on the preparation was discussed.The result of preliminary bioassay showed that some of the derivatives had antibacterial activity against staphylococcus aureus.
作者
刘冰
周勇
Liu Bing;Zhou Yong(School of Chemistry and Chemical Engineering,Xinxiang University,Xinxiang 453000,China)
出处
《河南师范大学学报（自然科学版）》
CAS
北大核心
2019年第6期71-75,共5页
Journal of Henan Normal University(Natural Science Edition)
基金
河南省科技攻关项目(192102310297)
关键词
苯佐卡因
溴代衍生物
抗菌活性
benzocaine
brominated derivatives
antibacterial activity
