摘要
目的研究染色体多态性与妊娠、妊娠期疾病、妊娠结局的关系。方法收集310对染色体多态性夫妇资料,分为女方多态组、男方多态组和双方多态组3组,对患者是否妊娠、妊娠期并发症和合并症、妊娠结局、围生儿出生身长、体质量等做跟踪随访。结果女方多态组流产率为12.24%(6/49),男方多态组流产率为11.76%(12/102),双方多态组流产率为33.33%(7/21),与男方多态组比较,双方多态组流产率明显增高,差异有统计学意义(P<0.05),与女方多态组比较,双方多态组流产率明显增高,但差异无统计学意义。而3组足月产率和早产率比较差异均无统计学意义。3组患者围产儿的活产率和死产率以及出生时体质量、身长差异均无统计学意义。多态性患者未足月胎膜早破(PPROM)的发生率高达4.46%。结论夫妻双方多态性与不良妊娠结局成正相关性。
Objective To explore the relationship of chromosomal polymorphism and pregnancy,pregnant diseases,pregnancy outcome.Methods 310 pairs of couples with chromosomal polymorphism were recruited and divided into three groups:wife-polymorphism group,husband-polymorphism group and both-polymorphism group.Their information of pregnancy or not,pregnant diseases,pregnancy outcome,perinatal fetus were followed up.Results The abortion rate of the female polymorphism group was 12.24%(6/49),the abortion rate of the male polymorphic group was 11.76%(12/102),and the abortion rate of the polymorphic group was 33.33%(7/21).Compared with the male polymorphism group,the abortion rate of the polymorphic group was significantly increased,and the difference was statistically significant(P<0.05).Compared with the female polymorphism group,the abortion rate of the polymorphic group was higher,but the difference was not statistically significant.There was no significant difference in the full-term yield and preterm birth rate between the 3 groups.There were no significant differences in live birth rate and stillbirth rate between the three groups of patients with perinatal birth weight and body weight and body length at birth.Rate of preterm premature rapture of membranes in couples with chromosomal polymorphism was 4.46%.Conclusion Polymorphism between husband and wife is positively correlated with adverse pregnancy outcomes.
作者
靳瑞华
叶四云
陈大蔚
章志国
周平
曹云霞
Jin Ruihua;Ye Siyun;Chen Dawei(Reproductive Medicine Center,Dept of Obstetrics and Gynecology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022;Fuyang Women s and Children s Hospital,Anhui Province,Fuyang 236000;Anhui Province Key Laboratory of Reproductive Health and Genetics,Anhui Medical University,Hefei 230022;Biopreservation and Artificial Organs,Anhui Provincial Engineering Research Center,Hefei 230022)
出处
《安徽医科大学学报》
CAS
北大核心
2019年第10期1620-1623,共4页
Acta Universitatis Medicinalis Anhui
基金
安徽省科技攻关计划项目(编号:1604a0802077)
关键词
染色体多态性
妊娠期疾病
妊娠结局
chromosomal polymorphism
pregnant diseases
pregnancy outcome