摘要
前列腺癌在美国成年男性中发病率位居第一,癌症相关致死率位居第二。雄激素剥夺治疗是最常用的前列腺癌治疗方法,而且通常伴随患者的终身治疗。雄激素和雄激素剥夺疗法对免疫系统有着重要的影响,在目前免疫治疗受到持续关注的情况下这一发现显得尤为重要。研究表明,雄激素剥夺治疗可能对免疫治疗起到促进或者抑制的作用。本文综述了不同类型雄激素剥夺治疗药物的作用机制,探讨了其对前列腺癌细胞及患者免疫系统的影响,以及联合使用雄激素剥夺药物和免疫治疗的前景,为前列腺癌的治疗提供了新的视野和思路。
Prostate cancer ranks first among adult males in the United States,and second in cancer-related mortality.Androgen deprivation therapy(ADT)is the most commonly used treatment for prostate cancer and is usually a lifelong treatment with the patient.Androgen and ADT have a profound impact on the immune system,and this finding is particularly important in the ear of current immunotherapy.Studies have shown that ADT may promote or inhibit immunotherapy.This article reviews the mechanism of action of different types of ADT drugs,discusses their effects on prostate cancer cells and immune system,and the prospect of combination of ADT and immunotherapy,to provide new thought and vision on the treatment of prostate cancer.
作者
朱晖
邓康俐
ZHU Hui;DENG Kangli(Glickman Urologic and Kidney Institute,Cleveland Clinic,9500 Euclid Ave.Q100,Cleveland,OH 44195,USA;Department of Urology,Hubei Cancer Hospital,Huazhong University of Science and Technology,Wuhan 430079,China)
出处
《肿瘤防治研究》
CAS
CSCD
2019年第10期867-872,共6页
Cancer Research on Prevention and Treatment
关键词
雄激素剥夺治疗
免疫治疗
前列腺癌
Androgen deprivation therapy
Immunotherapy
Prostate cancer
