摘要
目的:探究硝酸盐转运蛋白(Sialin)与口腔鳞状细胞癌预后的相关性。方法:收集2018年1月—2018年9月我院收治口腔鳞状细胞癌患者80例,取其癌组织,进行免疫组织化学检测法,检测Sialin和Ki-67表达情况,分析Sialin表达与口腔癌临床病理因素的相关性,以及Sialin和Ki-67的相关性。结果:Sialin的表达与肿瘤的分期、浸润程度以及分化程度有关(P<0.05);Sialin与Ki-67之间呈较强的正相关(Pearson相关系数为0.48,P<0.05)。结论:Sialin的表达和口腔鳞状细胞癌的发生发展相关,同时和Ki-67呈较强的正相关,是一个较好的预后因子。
Objective:To explore the correlation between nitrate transporter protein(Sialin)and prognosis of oral squamous cell carcinoma.Methods:80 patients with oral squamous cell carcinoma admitted to our hospital from January 2018 to September 2018 were collected and their cancer tissues were taken for immunohistochemical detection to detect the expression of Sialin and ki-67.The correlation between the expression of Sialin and the clinicopathological factors of oral cancer and the correlation between Sialin and ki-67 were analyzed.Results:the expression of Sialin was related to tumor stage,invasion degree and differentiation degree(P<0.05).There was a strong positive correlation between Sialin and ki-67(Pearson correlation coefficient was 0.48,P<0.05).Conclusion:the expression of Sialin is correlated with the occurrence and development of oral squamous cell carcinoma,and has a strong positive correlation with ki-67,which is a good prognostic factor.
作者
陈国栋
欧阳嘉杰
胡超
梁静仪
Chen Guodong(Stomatology Center,Shunde hospital,Southern Medical University(Foshan Shunde First People’s Hospital),Foshan Guangdong 528000)
出处
《黑龙江医药》
CAS
2019年第5期1019-1021,共3页
Heilongjiang Medicine journal
基金
佛山市自筹经费类科技计划项目(项目编号:2016AB003673)
南方医科大学科研启动计划项目(项目编号:PY2018N115)
关键词
硝酸盐转运蛋白
口腔鳞状细胞癌
预后
相关性研究
Nitrate transporter
Oral squamous cell carcinoma
The prognosis
Correlation study
