摘要
目的探讨血清总胆汁酸(TBA)、胆碱酯酶(CHE)测定在重症患者继发性肝损害中的诊断意义。方法选择宁夏医科大学总医院2015年10月-2017年6月急诊重症监护室收治的90例重症患者的临床资料,分为肝损害组及对照组(无肝损害组)。对两组患者一般临床资料进行分析比较,包括年龄、性别、住院时间、急性生理学和慢性健康状况系统评分(acute physiology and chronic health evaluationⅡ,APACHEⅡ)、机械通气时间;动态监测血清TBA、CHE等指标变化。结果肝损害组患者APACHE评分、第3、5、7天TBA均高于对照组(P均<0.05);第5、7天CHE均低于对照组(P均<0.05)。肝损害组TBA检测的敏感度及特异度分别是82.22%和75.00%,而CHE检测分别为66.67%和42.86%。结论TBA、CHE是检测肝功能比较灵敏的指标,其测定对判断早期继发性肝损害有一定诊断价值。
Objective To explore the diagnostic significance of serum total bile acid and cholinesterase in severe patients with secondary liver injury.Methods Ninety patients with severe illness admitted to the emergency intensive care unit of the General Hospital of Ningxia Medical University from October 2015 to June 2017 were divided into hepatic injury group and control group(non-hepatic injury group).The general clinical data of the two groups were analyzed and compared,including age,sex,length of stay,acute physiology and chronic health evaluation II(APACHEII)score,mechanical ventilation time,dynamic monitoring of serum total bile acid,cholinesterase and other indicators.Results The APACHE score,TBA on the 3rd,5th and 7th day in liver injury group were higher than those in control group(all P<0.05),and CHE on the 5th and 7th day were lower than those in control group(all P<0.05).The sensitivity and specificity of TBA in liver injury group were 82.22%and 75.00%respectively,while CHE was 66.67%and 42.86%respectively.Conclusion Serum total bile acid and serum cholinesterase are sensitive indicators of liver function.The determination of serum total bile acid and serum cholinesterase has certain application value in judging early secondary liver injury.
作者
马晓
杜武军
康向飞
李文峰
马磊
闫凤华
吴嘉荔
马汉宁
杨立山
MA Xiao;DU Wujun;KANG Xiangfei;LI Wenfeng;MA Lei;YAN Fenghua;WU Jiali;MA Hanning;YANG Lishan(Emergency department,the General Hospital of Ningxia Medical University,Yinchuan 750004,China)
出处
《宁夏医科大学学报》
2019年第6期604-606,共3页
Journal of Ningxia Medical University
基金
宁夏自治区卫计委课题(2015-NW-029)
