摘要
目的探讨多西他赛联合顺铂加参一胶囊治疗晚期胃癌的临床疗效。方法选取自2016年10月至2018年10月于北部战区总医院接受治疗的120例晚期胃癌患者为研究对象。将所有患者随机分为A、B两组,每组各60例。A组接受多西他赛联合顺铂治疗;B组在A组基础上加服参一胶囊。采用增强CT检查患者肿瘤体积;比较两组患者白细胞水平,肿瘤标志物CA724、CA199、CA50、CA242、CEA水平及不良反应发生情况。结果两组患者治疗前白细胞、肿瘤体积、肿瘤标志物水平比较,差异无统计学意义(P>0.05)。治疗后,B组患者白细胞水平显著高于A组,肿瘤体积及肿瘤标志物水平显著低于A组,两组比较,差异均有统计学意义(P<0.05)。B组不良反应发生率为6.7%(4/60),显著低于A组的26.7%(16/60),两组比较,差异有统计学意义(P<0.05)。结论多西他赛联合顺铂加参一胶囊治疗晚期胃癌能够更好的改善患者的治疗效果。
Objective To investigate the clinical effects of Docetaxel combined Cisplatin plus Shenyi capsule in patients advanced gastric cancer.Methods A retrospective study was performed on 120 cases of patients with advanced gastric cancer who were admitted from October 2016 to October 2018.All the patients were randomly divided into the Group A and Group B,with 60 cases in each group.Group A of patients received Docetaxel combined with Cisplatin.In Group B,Shenyi capsule was added on the basis of treatment like Group A.The tumor volume was examined by enhanced CT.The leucocyte levels,tumor markers CA724,CA199,CA50,CA242,CEA levels and adverse reactions were compared between the two groups.Results White blood cells,tumor volume and tumor markers of the two groups before treatment showed no statistically significant difference(P>0.05).After treatment,the leucocyte level in Group B was significantly higher than that in Group A,and the tumor volume and tumor marker level were significantly lower than that in Group A(P<0.05).The incidence of adverse reactions in Group B was 6.7%(4/60),which was significantly lower than that in Group A(26.7%,16/60),P<0.05.Conclusion Docetaxel combined with Cisplatin and Shenyi capsule in the treatment of advanced gastric cancer can better improve the therapeutic effect of patients.
作者
谭林深
朴瑛
郑振东
TAN Lin-shen;PIAO Ying;ZHENG Zhen-dong(Department of Oncology,General Hospital of Northern Theater Command,Shenyang 110016,China)
出处
《临床军医杂志》
CAS
2019年第9期905-907,共3页
Clinical Journal of Medical Officers
基金
辽宁省科学技术基金(20170540966)
关键词
晚期胃癌
参一胶囊
化疗
多西他赛
顺铂
Advanced gastric cancer
Shenyi capsule
Chemotherapy
Docetaxel
Cisplatin
