摘要
目的探讨醒脾养儿颗粒联合热毒宁、蒙脱石散治疗轮状病毒肠炎的疗效及对炎性反应、免疫功能的影响。方法选取医院2016年12月至2018年5月收治的轮状病毒肠炎患儿132例,按随机数字表法分为观察组和对照组,各66例。两组患儿入院后均给予补液、纠正水电解质失衡和内环境酸碱失衡等常规治疗,对照组给予热毒宁、蒙脱石散治疗,观察组在此基础上联用醒脾养儿颗粒治疗。两组均连续治疗5 d。结果观察组患儿的退热、止泻、大便性状恢复、止吐和住院时间均显著短于对照组(P<0.05);观察组总有效率为95.45%,明显高于对照组的84.85%(P<0.05);治疗后,两组患儿的C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)和白细胞介素6(IL-6)水平均明显低于治疗前,且观察组显著低于对照组(P<0.05);两组患儿的CD3+,CD4+,CD4+/CD8+水平均明显高于治疗前,且观察组高于对照组(P<0.05);两组均未见明显不良反应。结论醒脾养儿颗粒联合热毒宁、蒙脱石散治疗轮状病毒肠炎的疗效和安全性均较好,能快速改善症状,减轻机体炎性反应,提高免疫功能。
Objective To investigate the effect of Xingpi Yanger Granules combined with Reduning and Montmorillonite Powder in the treatment of rotavirus enteritis and its effect on inflammatory reaction and immune function.Methods Totally 132 children with rotavirus enteritis admitted to our hospital from December 2016 to May 2018 were selected and divided into the observation group and the control group according to the random number table method,66 cases in each group.After admission,the children in the two groups were given routine treatment such as fluid replacement,correction of water and electrolyte imbalance and acid-base imbalance of internal environment.On this basis,the children in the control group were treated with Reduning and Montmorillonite Powder,the children in the observation group were treated with Xingpi Yanger Granules on the basis of the control group.Both groups were treated continuously for 5 d.Results The defervescence time,antidiarrheal time,fecal character recovery time,antiemetic time and hospitalization time in the observation group were shorter than those in the control group(P<0.05).The total effective rate of the observation group was95.45%,which was significantly higher than 84.85%of the control group(P<0.05).After treatment,the levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the two groups were significantly lower than those before treatment,and those in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the levels of CD3+,CD4+and CD4+/CD8+in the two groups were significantly higher than those before treatment,and those in the observation group were higher than those in the control group(P<0.05).No obvious adverse reactions were found in the two groups.Conclusion Xingpi Yanger Granules combined with Reduning and Montmorillonite Powder are effective and safe in the treatment of rotavirus enteritis,which can quickly improve the symptoms,alleviate inflammation reaction and improve immune function.
作者
秦方芳
李秀敏
韩洁
QIN Fangfang;LI Xiumin;HAN Jie(The Second People′s Hospital of Liaocheng,Liaocheng,Shandong,China 252600)
出处
《中国药业》
CAS
2019年第19期71-73,共3页
China Pharmaceuticals
基金
山东省科技发展计划项目[2016GSF119023]
关键词
醒脾养儿颗粒
热毒宁
蒙脱石散
轮状病毒肠炎
疗效
Xingpi Yanger Granules
Reduning
Montmorillonite Powder
rotavirus enteritis
efficacy