摘要
上转换荧光纳米粒子具有优异的理化性质,如稳定的发光性能、可调的发射光谱及相对较低的生物毒性,使其在肿瘤治疗领域展现出较好的应用前景.但是很多上转换纳米粒子介导的肿瘤治疗在可控性及选择性方面仍存在不足,无法有效减小对正常组织的损伤,从而阻碍了其在肿瘤治疗中的进一步发展.合理的结构设计和功能化组装,可以构建上转换纳米粒子智能响应系统.这不仅弥补了传统肿瘤治疗的缺陷,也为开发具备可控性和选择性的肿瘤治疗方案提供了新的思路.本文主要对上转换纳米粒子智能响应药物系统的刺激因素及构建方式进行简要的分析,同时总结了它们在肿瘤治疗中的应用和研究现状,并在此基础上对它们在未来肿瘤治疗中的挑战进行了分析和展望.
Up-conversion fluorescent nanomaterials have excellent physical and chemical properties, such as stable luminescence, adjustable emission wavelength and lower toxicity, thus exhibiting extensive application prospect in cancer therapy. However, many up-conversion nanomaterials-mediated cancer therapies still have some defects in controllability and selectivity, which cannot reduce the damage to normal tissue, limiting its further development in cancer therapy. Through reasonable structural design and functional assembly, up-conversion nanomaterials can construct the intelligent response-type medication system, which not only makes up for the deficiency of traditional tumor treatment, but also provides new idea for the cancer therapy with controllability and selectivity. This paper mainly analyzes the stimulus and construction method of intelligent response-type medication system based on the upconversion nanomaterials. Meanwhile, it summarizes their application and research status in cancer therapy, and on this basis the analysis and prospect for their challenges in cancer therapy are given.
作者
张晨阳
晏亮
谷战军
Chenyang Zhang;Liang Yan;Zhanjun Gu(CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,Institute of High Energy Physics,Chinese Academy of Sciences,Beijing 100049,China;University of Chinese Academy of Sciences,Beijing 100049,China)
出处
《中国科学：化学》
CAS
CSCD
北大核心
2019年第9期1179-1191,共13页
SCIENTIA SINICA Chimica
基金
国家重点基础研究发展计划(编号:2016YFA2021600)
国家自然科学基金(编号:51822207,51772292,31571015,11621505,11435002,21320102003)
中国科学院青年创新促进会(编号:2013007)
中科院前沿科学重点研究计划(编号:QYZDJ-SSW-SLH022)资助项目
关键词
上转化荧光纳米粒子
内源刺激
外源刺激
智能响应
肿瘤治疗
up-conversion fluorescent nanomaterials
endogenous stimuli
exogenous stimuli
intelligent response
cancer therapy
