摘要
现有疫苗可有效预防病毒感染,但对于HPV已感染或已致病的个体却无有效治疗方法。HPV感染机制探索及防治策略研究仍需要合适的动物模型,由于病毒的宿主特异性,尚未建立理想的HPV感染动物模型,特别是HPV感染小鼠模型。2011年分离的小鼠乳头瘤病毒(MmuPV1),可自然感染实验室小鼠品系,并引发小鼠恶性肿瘤,是现有唯一可用于乳头瘤小鼠模型建立的病毒。MmuPV1感染小鼠模型具有动物体积小,易于操作,试剂盒丰富等诸多优点。因此,该小鼠模型为乳头瘤病毒感染研究的进一步深入提供了关键平台。本文通过综述MmuPV1感染小鼠模型创制及应用相关研究,更好地助力HPV的致病机制、防治策略等方面的研究。
Although available human papillomavirus(HPV)vaccines can effectively prevent HPV infection,there is still no effective treatment for individuals who are already infected.HPV exhibits species-specific tropism,thereby limiting understanding and research on HPV infection and carcinogenesis,and there are not ideal animal models,in particular mouse models,for HPV infection.In 2011,mouse papillomavirus type 1(MmuPV1)was isolated,which can naturally infect mouse strains,and induce different kinds of tumors like HPV,and it is also the only model available for studying HPV-related diseases.This optimal model is widely used,for the reason that the MmuPV1-infection mouse model is a key tool for research because of its small size,easy modification,and the availability of abundant commercial reagents,and so on.Therefore,this mouse infection model provides us with a critical platform for extended HPV studies.In the current review,we summarized related studies about MmuPV1,in order to better facilitate new research on the pathogenesis,prevention and treatment of HPV infection.
作者
李丹
王卫
LI Dan;WANG Wei(Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences(CAMS),Comparative Medicine Center,Peking Union Medical College(PUMC),Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious Diseases,NHC Key Laboratory of Human Disease Comparative Medicine,Beijing 100021,China)
出处
《中国比较医学杂志》
CAS
北大核心
2019年第9期120-126,共7页
Chinese Journal of Comparative Medicine
基金
中国医学科学院医学与健康科技创新工程项目(2017-I2M-B&R-11)
国家传染病防治重大专项(2017ZX10304402-001-022)
中央级公益性科研院所基本科研业务费(2018JT35001)
关键词
人乳头瘤病毒小鼠
动物模型
human papillomavirus(HPV)
mouse
animal model
