摘要
STR基因座突变是亲子鉴定中较为常见的现象,本研究采用Golden-20A试剂盒对306例结论为"肯定"的亲子鉴定案例进行基因分型检测,观察和分析亲子鉴定案件中20个短串联重复序列(STR)基因座的突变现象,对不满足遗传规律的案件,分析其基因座及等位基因的相应特征。结果表明在306例亲子鉴定案例中,共观察到8例基因突变,其中一步突变为7例,二步突变为1例,涉及6个STR基因座。8例突变中,父系来源突变和母系来源突变的比例为3:1。通过本研究可知STR基因座突变的特点,司法鉴定中应不断积累突变数据,谨慎做出判断,以保证鉴定结果的准确性。
STR loci mutation is common phenomenon in paternity tests.A total of 306 cases of confirmed parentage testing were genotyped using the Golden-20 A kit. To observe and analyze the mutation phenomenon of20 STR loci in paternity tests. The corresponding characteristics of loci and alleles for those that do not conform to genetic laws were analysed. The results showed that among the 306 confirmed paternity cases, a total of 8 mutation events were observed, including 7 cases with single locus mutation and 1 case with mutations in two loci, relating to 6 STR loci. In 8 cases, the proportion of the paternal mutations and the maternal mutations was 3:1. According to the results of this study, we could know the characteristics of STR loci mutation, the data of STR loci mutations should be constantly accumulated in judicial identification, we should make a conclusion with great cautions in the cases to ensure accurate identification results.
作者
苏丽娟
王忆霄
单鑫
邱阳
席世涵
扈瑞平
Su Lijuan;Wang Yixiao;Shan Xin;Qiu Yang;Xi Shihan;Hu Ruiping(Basic Medical College,Inner Mongolia Medical University,Huhhot,010050)
出处
《基因组学与应用生物学》
CAS
CSCD
北大核心
2019年第8期3511-3514,共4页
Genomics and Applied Biology
基金
内蒙古医科大学2016年度高等教育教学改革研究项目(编号NYJXGG2016014)
内蒙古医科大学实验室开放基金项目(编号2016ZN21)共同资助
关键词
法医物证学
亲子鉴定
突变
STR
Forensic physical evidence
Parentage testing
Mutation
STR
