摘要
1例54岁女性患者,因颅内感染、鞍上池蛛网膜囊肿术后入院,给予伏立康唑(200 mg,bid,ivgtt)抗感染,10 d后改为伏立康唑(400 mg,bid,ivgtt)。应用抗真菌药物15 d后,患者出现幻觉。考虑为伏立康唑引起的神经损害,停用伏立康唑,给予奥氮平片治疗幻觉、氟康唑注射液治疗颅内感染,3 d后幻觉消失,颅内感染治疗持续20 d,患者逐渐恢复出院。
One 54-year-old female patient was hospitalized with intracranial infection and postoperation of suprasellar cistern arachnoid cyst.The patient was intravenously administered voriconazole 200 mg twice a day.After the tenth day,voriconazole was added to 400 mg twice a day.After 15 days of antifungal treatment,the patient suffered from illusion.Considering neurological damage caused by voriconazole,voriconazole was stopped immediately,and the patient was given olanzapine tablets and fluconazole injection for the treatment of illusion and intracranial infection.Three days later,the patient's illusion decreased.Twenty days later,the intracranial infection gradually relieved,and the patient was discharged.
作者
雷露
乔逸
杨志福
文爱东
LEI Lu;QIAO Yi;YANG Zhi-fu;WEN Ai-dong(Department of Pharmacy,Xijing Hospital,Air Force Military Medical University,Xi'an 710032,China;School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing 211198,China)
出处
《中国药物应用与监测》
CAS
2019年第4期246-248,共3页
Chinese Journal of Drug Application and Monitoring
基金
国家自然科学基金项目(81573549)
关键词
伏立康唑
幻觉
药品不良反应
Voriconazole
Illusion
Adverse drug reaction