摘要
目的探讨脑梗死病人上肢功能状况与功能性磁共振(fMRI)成像特征的相关性。方法采用回顾性研究方法,选择2013年8月—2016年2月在我院诊治的脑梗死病人72例作为观察组,选择72名同期正常查体者作为对照组。两组均进行上肢功能状况与神经功能评分、常规核磁共振(MRI)与fMRI诊断,并且进行相关性分析。结果观察组上肢功能状况与神经功能评分分别为(44.52±5.29)分和(8.20±1.45)分,对照组分别为(70.20±6.19)分和(4.20±1.92)分,两组对比差异有统计学意义(P<0.05)。观察组与对照组灰白质信号强度分别为(188.20±16.30)dBm和(254.20±15.20)dBm,观察组明显低于对照组(t=5.208,P<0.05)。观察组的前额叶背外侧部、扣带回前部、顶叶后下部的功能信号图像激活脑区体素明显低于对照组(P<0.05)。直线性相关分析显示,上肢功能评分与灰白质信号强度、前额叶背外侧部体素、扣带回前部体素、顶叶后下部体素呈正相关(r值分别为0.612、0.672、0.452、0.389,P<0.05);美国国立卫生研究院卒中量表(NIHSS)评分与灰白质信号强度、前额叶背外侧部体素、扣带回前部体素、顶叶后下部体素则呈负相关(r值分别为-0.372、-0.299、-0.452、-0.410,P<0.05)。结论脑梗死病人多伴有上肢功能障碍,fMRI显示出明显的影像学异常,且fMRI成像可反映病人的上肢运动功能状况,对脑梗死病人临床预后评估具有重要临床价值。
Objective To investigate the correlation between upper limb function and functional magnetic resonance imaging(fMRI)in patients with cerebral infarction.Methods Seventy-two patients with cerebral infarction were selected as the observation group,and 72 healthy persons were selected as the control group.Upper limb,neurological function score,conventional MRI and fMRI diagnosis were performed in the two groups,and correlation analysis was performed.Results The upper limbs and neurological function scores in the observation group were(44.52±5.29)dBm and(8.20±1.45)dBm,while that in the control group were(70.20±6.19)and(4.20±1.92),(P<0.05).The gray signal strength in the observation group was significantly lower than that in the control group(P<0.05).In the observation group,the functional signal images of the dorsolateral prefrontal lobe,anterior cingulate gyrus,and posterior parietal lobe activated voxel were significantly lower than those in the control group.Linear correlation analysis showed that upper limb function scores were positive correlated to signal intensity of grays,dorsolateral prefrontal cortex,anterior cingulate,gyrus and posterior inferior parietal cortex(r=0.612,0.672,0.452,0.389,P<0.05);National Institutes of Health Stroke Scale scores were showed significant negative correlation(r=-0.372,-0.299,-0.452,-0.410,P<0.05).Conclusion Most patients with cerebral infarction had upper limb dysfunction,fMRI showed obvious radiographic abnormalities,and fMRI imaging reflected the patients with upper limb function.
作者
闵朋
杨锐
MIN Peng;YANG Rui(Dongfeng Hospital Affiliated to Hubei University of Medicine,Shiyan 442000,Hubei,China)
出处
《中西医结合心脑血管病杂志》
2019年第15期2369-2372,共4页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金
2018年十堰市科学技术研究与开发项目(No.18Y91)
关键词
脑梗死
上肢功能
神经功能
功能性磁共振成像
相关性
临床价值
cerebral infarction
upper limb function
neurological function
functional magnetic resonance imaging
correlation
clinical value
