摘要
患者女,36岁,头皮黑点10余年。体检:头部散在多个毛囊性黑点。皮肤镜下表现为黑点征、逗号发和螺旋发。头屑真菌荧光染色可见大量孢子。真菌培养可见紫红色菌落,小培养镜下可见短粗、分隔菌丝和厚壁孢子。临床分离菌株进行nrDNA ITS扩增测序,所得序列与GenBank中紫色毛癣菌序列同源性99%。诊断为紫色毛癣菌所致黑点癣。治疗:伊曲康唑0.2g/d口服,酮康唑洗剂洗头,特比萘芬喷剂外用,4周后患者痊愈,目前仍在随访中。
A 36-year-old female patient presented to our clinic with complaints of black dots on the scalp for more than 10 years.The signs of black dots,comma hair and corkscrew hair could be seen in the dermatoscope.Direct fungal fluorescence microscopic examination showed a large amount of spores.Culture on Sabouraud dextrose agar revealed purple colonies,short-thick septa hyphae and chlamydospores could be found on the slide culture.Trichophyton violaceum was identified as the causative phathogen by nrDNA ITS sequencing.Oral itraconazole(0.2g/d)was administered to this patient combined with topical application of ketoconazole lotion and terbinafine spray.After 4 weeks treatment,the patient was cured and was still in the follow-up now.
作者
谢振谋
曾维英
黄进梅
刘应辉
欧江丽
刘红芳
XIE Zhen-mou;ZENG Wei-ying;HUANG Jin-mei;LIU Ying-hui;OU Jiang-li;LIU Hong-fang(Department of Laboratory,Dermatology Hospital,Southern Medical University,Guangzhou 510091;Department of Dermatology,Dermatology Hospital,Southern Medical University,Guangzhou 510091,China)
出处
《中国真菌学杂志》
CSCD
2019年第4期235-237,共3页
Chinese Journal of Mycology
基金
国家自然科学基金青年项目(81601746)
广东省公益研究与能力建设专项基金(2014A020212679)
关键词
紫色毛癣菌
黑点癣
皮肤镜
伊曲康唑
black-dot ringworm
dermatoscope
Trichophyton violaceum
itraconazole
