摘要
目的 探讨罂粟碱血管内介入治疗脑血管痉挛的可行性和效果 .方法 成年杂种犬 30只 ,基底动脉痉挛采用枕大池两次注血模型 .随机分为 :罂粟碱动脉内介入治疗 (IAP)组 (n=2 0 ) ,治疗微导管超选择性置入痉挛血管近端的基底或椎动脉 ,药物浓度和注射速度分别为 1g· L- 1 和 1m L·min- 1 ;静脉点滴 (VD)组 (n=10 ) ,药物点滴浓度和速度与IAP组相同 .两组动物治疗前后及治疗过程中均进行脑血管造影 ,评价疗效 .结果 两组动物血管痉挛程度无显著差异(P>0 .0 5 ) .治疗后 IAP组血管痉挛得到明显缓解为 6 5 %(13/ 2 0 ) ,而 VD组则仅有 2 0 % (2 / 10 ,P<0 .0 5 ) .
AIM To study the effects of treatment cerebral vasospasm with intra arterial infusion of papaverine (IAP). METHODS Thirty adult mongrel canines of both genders served as the subject. Basilar artery (BA) vasospasm was induced by twice injecting autologous artery blood into the brain cisterns. The canines were randomly divided into 2 groups: IAP groups, microcatheters were introduced justproximal to the site of vasospasm for superselective infusion of papaverine at a concentration of 1 g·L -1 and a rate of 2 mL·min -1 under angiographic monitoring; intravenousdrip (VD) groups, the concentration and infusion rate of papaverine was same as in the IAP groups, and angiographic monitoring was also throughout the treating. RESULTS There was no significant differince between the two groups both in diameter of normal BA and in degree of BA vasospasm ( P >0.05). Following the two difference procedure, 65% (13/20) of canines in IAP groups showed immediate angiographic enlargement of the BA and/or posterior cerebral artery lumen, while it was only 20% (2/10) in VD groups, and there were significant differince between these two groups ( P < 0.05 ). CONCLUSION IAP vasodilation was effictive for treament of vasospasm .
出处
《第四军医大学学报》
北大核心
2002年第19期1814-1816,共3页
Journal of the Fourth Military Medical University
关键词
脑血管痉挛
介入治疗
罂粟碱
犬
cerebral vasospasm
angioplasty
papaverine
canine
