摘要
目的 :观察赖诺普利与非洛地平联用对原发性高血压 (EH)伴左室肥厚 (LVH)的逆转效果。方法 :将 82例EH伴LVH患者随机分为A组 (单用赖诺普利 ) 4 0例 ,B组 (赖诺普利与非洛地平缓释片联用 ) 4 2例。观察两组治疗前后及两组间血压及LVH指标的变化。结果 :6个月后两组血压均较治疗前明显下降 (P <0 .0 1) ,组间降压幅度差异无显著性意义 (P >0 .0 5 ) ;两组左室重量指数均较治疗前明显降低 (P <0 .0 1) ,B组较A组更明显 (P <0 .0 5 )。结论 :两药联用对LVH逆转有协同作用。
Objective:To observe the antihypertensive effect of felodipine retard combined with lisinopril and their effects on reducing left ventricular hypertrophy in essential hypertension (EH). Methods:Eighty two patients with EH were randomly divided into lisinopril treatment group (40 cases) and lisinopril plus felodipine treatment group (42 cases). The indexes of the observation included the variety of blood pressure and left ventricular hypertrophy after 6 months treatment in both groups. Results:It was found that blood pressue was significantly decreased in both groups after 6 months treatment (P< 0.01 ), but no difference was found in the level of blood pressure reduction between these two groups (P> 0.05 ). Index of left ventricular mass reduced significantly in both groups (P< 0.01 ), moreover, this effect was more obvious in the combined treatment group than that in the lisinopril treatment group (P< 0.05 ).Conclusion:Felodipine combined with lisinopril may cause added effect in reduction of left ventricular remodeling.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2002年第8期373-374,共2页
Journal of Clinical Cardiology
关键词
高血压
赖诺普利
非洛地平
左心室肥厚
Lisinopril
Felodipine
Hypertension
Left ventricular hypertrophy
