摘要
目的 了解Bcl- 2和p5 3蛋白在子宫平滑肌肿瘤 (USMTs)的表达和意义。方法 在 2 0例良性子宫平滑肌瘤 (UL)、18例子宫平滑肌肉瘤 (LMS)及 70例交界性子宫平滑肌瘤 (BLM) :包括 4 0例富于细胞型子宫平滑肌瘤 (CL)、13例奇异型子宫平滑肌瘤 (BL)、4例核分裂活跃型子宫平滑肌瘤 (ML)、10例不典型子宫平滑肌瘤 (AL)及 3例恶性潜能未定型子宫平滑肌瘤 (STUMP)应用免疫组织化学法检测Bcl- 2和p5 3蛋白的表达。结果 UL组bcl- 2蛋白表达阳性率明显高于LMS组 (P <0 .0 5 ) ;BLM组bcl- 2蛋白表达阳性率显著高于LMS组 (P <0 .0 1)。LMS组p5 3蛋白表达阳性率显著高于UL组 (P <0 .0 1)和BLM组 (P <0 .0 1)。结论 本研究结果提示 :细胞凋亡旁路的抑制即通过Bcl- 2和p5 3蛋白的过度表达可能在USMT的发生。
Objective To investigate the expression and significance of Bcl 2 and p53 protein in human uterine smooth muscle tumors (USMTs). Methods Immunohistochemical technique was used to detect the Bcl 2 and p53 protein expressions in: 20 usual leiomyoma (UL), 70 borderline leiomyoma (BLM): including 40 cellular leiomyoma (CL), 13 bizarre leiomyoma (BL), 4 mitotically active leiomyoma (ML), 10 atypial leiomyoma (AL), 3 smooth muscle tumors of uncertain malignant potential (STUMP) and 18 leiomyosarcoma (LMS). Results The positive Bcl 2 protein expression rate of UL was apparently higher than that of LMS ( P <0.05); The positive Bcl 2 protein expression rate of BLM was clearly higher than that of LMS ( P <0.01). The positive p53 protein expression rate of LMS was clearly higher than that of UL ( P <0.01) and BLM ( P <0.01) . Conclusion The results suggest that an inhibition of the induction of apoptosis,either by Bcl 2 or by p53 protein overexpression might play an important role in human uterine smooth muscle tumors.
出处
《中国实验诊断学》
2002年第5期288-291,共4页
Chinese Journal of Laboratory Diagnosis
