摘要
16只健康 AA肉仔鸡 ,随机分成 2组 ,每组 8只 ,按 10 mg/ kg剂量分别进行静注和内服单剂量环丙沙星药动学试验。血浆中药物浓度用高效液相色谱法测定 ,血药浓度 -时间数据用 MCPKP药动学计算机程序处理。结果表明 ,静注给药后的药时数据符合无吸收二室开放模型 ,主要动力学参数分别为 :t1 /2α为 (0 .2 34± 0 .0 49) h,t1 /2β为 (10 .118±0 .2 71) h,VB为 (1.374± 0 .12 4) L/ kg,CLB为 (0 .0 94± 0 .0 0 9) L· kg- 1 · h- 1 ,AUC为 (10 7.0 6 8± 10 .6 40 ) mg· L- 1· h。内服给药后的药时数据符合一级吸收一室开放模型 ,主要动力学参数分别为 :t1 /2 kα为 (0 .114± 0 .0 0 8) h,t1 /2 k为(7.784± 0 .5 14) h,Tp 为 (0 .70 2± 0 .0 31) h,Cmax为 (5 .736± 0 .5 15 ) m g/ L,AUC为 (6 8.6 2 2± 8.147) mg· L- 1· h,F为 (6 4.0 92± 7.6 10 ) %。肉仔鸡静注环丙沙星在其体内消除较慢 ,分布广泛 ;内服给药吸收迅速 ,消除较静注给药快。
Sixteen broiler chickens were divided into two groups by intravenous and oral administration.Plasma concentrations of ciprofloxacin were determined by HPLC method after intravenous and orally administered doses of 10 mg/kg of body weight.The concentration-time data of ciprofloxacin in plasma were analyzed with MCPKP program.The results showed that the concentration-time data of ciprofloxacin in plasma after intravenous administration in healthy broiler chickens are fitted to a two-compartment open model.The main pharmacokinetic parameters are as follows:t 1/2α,(0.234±0.049) h;t 1/2β,(10.118±0.271) h,V B,(1.374±0.124) L/kg,CL B,(0.094±0.009) L·kg -1·h -1,AUC,(107.068±10.640) mg·L -1·h?A one-compartment open model describes the concentrations-time data of ciprofloxacin in plasma following oral administration in healthy broiler chickens.The main pharmacokinetic parameters are as follows:t 1/2kα,(0.114±0.008) h;t 1/2k,(7.784±0.514) h,T p,(0.702±0.031) h,C max,(5.736±0.515) mg/L;AUC,(68.622±8.147) mg·L -1·h;F,(64.092±7.610)%.After intravenous administration of ciprofloxacin in broiler chickens,elimination was slow and distribution in body was wide.After oral administration of ciprofloxacin,absorption was very speed and elimination was faster than intravenous administration.
出处
《中国兽医学报》
CAS
CSCD
北大核心
2002年第6期617-619,共3页
Chinese Journal of Veterinary Science
