摘要
目的 :研究治糖保肾冲剂治疗早期糖尿病肾病的机理。方法 :采用随机、对照法研究治糖保肾冲剂的临床作用机制。结果 :治糖保肾冲剂加苯那普利组能明显减少ET - 1,升高 6 -Keto -PGF1α、降低TXB2 ,减少LPO的产生和增加SOD(P <0 .0 5 ,0 .0 1)。而苯那普利组的作用与治疗前相比不明显。结论 :治糖保肾冲剂可能通过减少ET - 1,升高 6 -Keto -PGF1α、降低TXB2 ,减少LPO的产生和增加SOD对早期糖尿病肾病起治疗作用。
Objective:To study of the mechanism of Zhitang Baoshen Granule in early diabetic nephropathy.Methods: with Zhitang Baoshen Granule and Benazipril;control group with 30 cases treated with Benazipril.Results:In treatment group the blood ET-1,TXB 2,LPO significantly reduced ( P <0.05~0.01)and the 6-Keto-PGF 1α increased( P <0.05);in control group only TXB 2 significantly reduced,6-Keto-PGF 1α increased ( P <0.05).Conclusion:The Zhitang Baoshen Granule could reduce ET-1,TXB 2,LPO and increase 6-Keto-PGF 1α in patients with early diabetic nephropathy.
出处
《中国中西医结合肾病杂志》
2002年第10期573-574,共2页
Chinese Journal of Integrated Traditional and Western Nephrology