摘要
目的 观察血清CHE及PA水平在各组肝病中的表现 ,探寻能更好地反映肝脏合成蛋白功能的指标。方法 测定313例共 7组肝脏疾病及 36例正常对照组的血清CHE及PA水平 ,进行统计学处理 ;同时常规测定血清TP及A水平。结果 血清CHE活性测定 ,急性肝炎、慢性活动性肝炎、重症肝炎、肝硬化、原发性肝癌活性下降 ,与对照组比较P <0 .0 0 1;脂肪肝活性升高 ,P <0 .0 0 5 ;慢性迁延性肝炎活性变化不大 ,P >0 .0 5。血清PA测定 ,慢性迁延性肝炎、脂肪肝变化不大 ,P >0 .5 0 ;其它各组肝病均出现浓度下降 ,P <0 .0 0 1。血清TP浓度在各组肝病中变化不大。血清A浓度在慢性活动性肝炎、肝硬化、重症肝炎、原发性肝癌降低 ,急性肝炎偶见降低。结论 血清CHE活性及PA浓度测定较之血清TP及A浓度测定 ,更能及时地反映肝脏细胞合成蛋白能力。
Objective To observe the levels of serum CHE and PA in patients with hepatopathy and to search for an index which can reflect the synthetic proteins function of liver better.Method The levels of serum CHE and PA in 313 patients in 7 groups with different hepatopathy and 36 normal individuals were determined and analyzed with statistics methods.The serum TP and A levels were determined routinely at the same time.Results The serum CHE level descended in patients with acute hepatitis,chronic active hepatitis,hepatitis gravis,liver cirrhosis and primary liver carcinoma,in contrast with control group,P<0.001.In patients with fatty liver the serum CHE level rose(P<0.005),in patients with chronic persistent hepatitis it changed a little(P>0.05).The serum PA level didn't change in patients with chronic persistent hepatitis and fatty liver(P>0.50),and in other patients with different hepatopathy it descended(P<0.001).The serum TP level didn't change in all patients.The serum A level reduced in patients with chronic active hepatitis,liver cirrhosis,hepatitis gravis,primary liver carcinoma,and in acute hepatitis it reduced casually.Conclusions In contrast with the level of TP and A,the level of CHE and PA in serum could reflect the synthetic proteins function more timely.
出处
《现代诊断与治疗》
CAS
2002年第6期333-335,共3页
Modern Diagnosis and Treatment
