摘要
目的 评价莫西沙星治疗轻中度急性无合并症的皮肤感染者的安全性和有效性。方法 采用随机双盲平行对照方法 ,对莫西沙星 40 0mg 1次 /d口服与左旋氧氟沙星 2 0 0mg 2次 /d口服进行对比观察。 结果 治疗结束后第1天 ,符合方案人群 (PP人群 )临床有效率 :试验组 92 .5 % ,对照组 71.4%。经统计学检验试验组有效率优于对照组。细菌学清除率试验组 10 0 % ,对照组为 93 .3 % ,差异无显著性。两组均未发现严重的药物不良反应。结论 莫西沙星治疗皮肤感染的疗效较好 ,无严重不良反应事件出现。
Objective To evaluate the efficacy and safety of moxifloxacin in the treatment of patients with acute uncomplicated skin infection.Methods A randomized double blind compared study was used to compare the efficacy and safety of moxifloxacin 400mg tablets,orally,once daily to levofloxacin 200mg tablets,orally,twice daily in the treatment of patients with acute uncomplicated skin infection.Results In the PP population,1 day post treatment efficacy rates were 95.5% for moxifloxacin vs.71.4% for levofloxacin,the efficacy rate of moxifloxacin was statistically better than that of levofloxacin and the rates of bacteriological eradication were 100.0% for moxifloxacin vs.93.3% for levofloxacin,and the difference of bacteriological eradication rates in two groups was no statistically significant.There were no serious adverse drug reactions in clinical trial.Conclusion The clinical and bacteriological efficacy and safety of moxifloxacin are better.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2002年第6期379-381,共3页
The Chinese Journal of Dermatovenereology
