Chromatin and DNA chain fragmentation studies on apoptosis in immune cells induced by ^(235)U and radioprotection of IL-2 or IL-6

Chromatin and DNA chain fragmentation studies on apoptosis in immune cells induced by 235 U and radioprotection of IL 2 or IL 6

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摘要ＣｈｒｏｍａｔｉｎａｎｄＤＮＡｃｈａｉｎｆｒａｇｍｅｎｔａｔｉｏｎｓｔｕｄｉｅｓｏｎａｐｏｐｔｏｓｉｓｉｎｉｍｍｕｎｅｃｅｌｓｉｎｄｕｃｅｄｂｙ２３５ＵａｎｄｒａｄｉｏｐｒｏｔｅｃｔｉｏｎｏｆＩＬ２ｏｒＩＬ６ＺｈｕＳｈｏｕＰｅｎｇ，Ｚｈａｎｇ... The apoptosis in human acute lymphoblastic leukemia cell line Molt 4 cell and macrophage cell line Ana 1 cell are studied after internal irradiation with enriched uranium 235 U. The cumulative absorption dose of 235 U in cultural cells through different periods are estimated. The fluorescence microscopic observations indicate that Molt 4 and Ana 1 immune cells internally irradiated by 235 U displayed significant chromatin fragmentation and marked pyknosis in immune cells nuclei, as well as DNA chain fragmentation and apoptotic bodies formation. It should be noted that DNA chain fragmentation induced by 235 U may be inhibited statistically by IL 2 (interleukin 2) or IL 6 treatment.

作者 Zhu Shou Peng, Zhang Lan Sheng and Fu Qiang ( Suzhou Medical College, Suzhou 215007 )

出处《Nuclear Science and Techniques》 SCIE CAS CSCD 1998年第1期49-51,共3页 核技术（英文）

关键词 DNA 染色质免疫细胞 ^235U Chromatin, DNA chain fragmentation,Apoptosis, Molt 4 cell, Ana 1 cell, Enriched uranium, IL 2, IL 6

分类号 Q522 [生物学—生物化学]

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Nuclear Science and Techniques

1998年第1期

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Chromatin and DNA chain fragmentation studies on apoptosis in immune cells induced by ^(235)U and radioprotection of IL-2 or IL-6

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