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复发性脑梗死与血管紧张素转换酶基因多态性的关系 被引量:1

Relationship between Recurrent Cerebral Infarction and Angiotensin I-Converting Enzyme(ACE)Gene Polymorphism
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摘要 目的 :评价血管紧张素转换酶 (ACE)基因多态性与脑梗死发生和复发及其危险因素的关系。方法 :测定复发及首发性脑梗死患者各60例 ,提取DNA做ACE基因多态性检测。结果 :DD基因型频率和D等位基因频率在复发性脑梗死患者中明显增加 (均P<0.01)。伴有高血压脑梗死患者DD基因型频率明显高于无高血压患者(P<0.05) ,且伴有脑血管病 (CVD)家族史者DI基因型明显高于无家族史者 (P<0.01)。结论 :ACE基因多态性可能和脑梗死的复发有关 ,在高血压人群和有脑血管病家族史的人群中进行ACE基因调查 ,可及早发现脑梗死发生和复发的高危人群 ,对脑梗死的防治意义重大。 Objective:To investigate the relationship between recurrent infarction and angiotensin I_converting enzyme(ACE)gene polymorphism.Methods:To study ACE gene in 60 patients with recurrent cerebral infarction,60 patients with first cerebr al infarction,and 60 controls by polymerase chain reaction(PCR).Results:DD geno type was significantly higher in recurrent cerebral infarction group(P<0.01),and the same trends have been shown in hypertensive cerebral infarction and DI geno type with family history of stroke(P<0.01).Conclusion:DD genotype was probably involved in the development of recurrent cerebral infarction,DD genotype in pati ents with hypertension and DI genotype in people with family history of stroke i ncreased the risk of recurrent cerebral infarction.
出处 《天津医药》 CAS 北大核心 2002年第11期672-673,共2页 Tianjin Medical Journal
关键词 血管紧张素原基因 多态现象 遗传学 脑梗塞 ACE 相关性 recurrent cerebral infarction ACE genotype hypertension family history of stroke
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  • 1[1]Moeda Y, Ikeda U, Ebata H, et al. Angiotensin- converting enzyme gene polymorphism in hypertensive individuals with parental history of stroke. Stroke, 1996, 27: 1521~ 3. 被引量:1
  • 2[2]Catto A, Carter AM,Barrett JH, et al. Angiotensin - converting enzyme inserting/ deletion polymorphism and cerebrovescular disease. Stroke, 1998, 27: 435~40. 被引量:1
  • 3[3]Han SY, Kwon Y J, Jo SK, et al. ACE gene polymorphism and renal responsiveness to ACE inhibitors in IgA nephropathy pa tients. Korean J Intern Med, 2000, 15(1): 13~8. 被引量:1

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