摘要
观察葛根素对急性冠状动脉综合征 (ACS)肱动脉流量介导性舒张 (FMD)功能的改善作用。采用随机、单盲方法将 60例 ACS患者分为葛根素治疗组 (3 4例 )和常规治疗组 (2 6例 ) ,并与正常组 (2 0例 )比较。经过相关指标检测发现 :1 ACS患者肱动脉 FMD功能较正常人明显减弱 ,CEC数及 ET-1水平明显高于正常人 (P值均 <0 .0 1 ) ;2治疗后葛根素组 FMD功能明显增强 ,与常规治疗组比较有非常显著性差异 (P<0 .0 0 1 ) ,CEC数及 ET-1含量亦显著减少 (P均 <0 .0 1 ) ;3葛根素组疗程结束前 1周平均心绞痛发作次数减少与 FMD功能增强及 ET-1含量减少有明显相关性。结论 :葛根素可显著改善 ACS患者的血管内皮功能异常 ,修复和保护内皮功能可能是葛根素抗心绞痛作用的重要机制之一。
To observe the protective effects of puerarin on the endothelial dysfunction in the patients with acute coronary syndrome(ACS),60 cases were divided into puerarin group(G1,n=34),and routine treatment group(G2,n=26)according to the randomized or single blind trial,and then the results were compared with the normal group(G3,n=20).After the related indexes were examined,the results showed that the flow mediated dilatation(FMD)function of ACS was obviously lower,while the number of circulating endothelial cells(CEC) and levels of plasma endothelin 1(ET 1)higher than that of normal people(P<0.01);The FMD function of G1 was greatly increased(P<0.001),while the CEC and ET 1 decreased in comparison with G3(P<0.01);The frequency of typical angina of G1 in the last week of treatment was obviously lower than that of G2,and this was closely correlated with the increased FMD function and the decreased ET 1 values.It indicates that the puerarin was effective on improving the FMD function and relieving of angina in patients with ACS.\;
出处
《福建中医学院学报》
2002年第4期11-13,共3页
Journal of Fujian College of Traditional Chinese Medicine
