摘要
目的探究女性绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)和合并代谢综合征(metabolic syndrome,MS)的相关危险因素。方法选取2017年3月至2018年1月在聊城大学营养中心和聊城市人民医院体检的绝经后妇女266例,包括非绝经后骨质疏松症(non-PMOP,N-PMOP)患者122例,PMOP患者144例,其中合并MS的PMOP(MS-PMOP)患者69例。采集其骨密度及脂代谢指标,统计分析PMOP和合并MS患者的脂代谢指标与骨密度的关系和PMOP发生的危险因素。结果MS-PMOP的发生与年龄、空腹血糖(fasting plasma glucose,FPG)、收缩压(systolic blood pressure,SBP)、舒张压(diastolic blood pressure,DBP)、低密度脂蛋白(low density lipoprotein cholesterol,LDL-C)、血同型半胱氨酸(homocysteine,HCY)含量均呈负相关(P<0. 05),与高密度脂蛋白(high-density lipoprotein cholesterol,HDL-C)、血清钙(calcium,Ca)、血清磷(phosphorus,P)含量呈正相关(P<0. 05)。PMOP和N-PMOP两组研究对象的年龄差异显著,并且PMOP组患者的SBP、DBP、FPG和HCY均值显著高于N-PMOP组(P<0. 05)。此外,PMOP组患者的HDL-C均值低于N-PMOP组(P<0. 05)。PMOP组患者的DBP、FPG、HDL-C、HCY均值低于MS-PMOP组(P<0. 05)。Logistic分析结果显示,SBP、FPG的增高和HDL-C的降低都是PMOP的危险因素。结论脂代谢异常、HCY增高等都有可能影响骨代谢,加剧PMOP发生;除此之外,MS患者SBP、FPG的增高,HDL-C的降低均是PMOP的危险因素,MS患者作为多种代谢异常的聚集体,是PMOP发生的高危人群。
Objective To explore the risk factors of postmenopausal osteoporosis(PMOP) and metabolic syndrome(MS) in women, and to provide the basis for their clinical prevention and treatment. Methods A total of 266 postmenopausal women who underwent physical examination at Liaocheng University Nutrition Center and Liaocheng People′s Hospital from March 2017 to January 2018 were enrolled, including 122 postmenopausal non-osteoporosis(N-PMOP) patients and 134 patients with PMOP including 69 patients accompanied by MS(MS-PMOP). Data on bone mineral density(BMD) and lipid metabolism were collected, and the relationship between lipid metabolism index and BMD in PMOP and MS patients, and the risk factors of PMOP were statistically analyzed. Results The occurrence of MS-PMOP was positively correlated with height, high density lipoprotein(HDL-C), serum calcium(Ca) and serum phosphorus(P)(P<0.05), and was negatively correlated with age, fasting blood glucose(FPG), systolic blood pressure(SBP), diastolic blood pressure(DBP), low density lipoprotein(LDL-C) and blood homocysteine(HCY)(P<0.05). The age of patients in the PMOP and N-PMOP groups was significantly different, and SBP, DBP, FPG and HCY of patients in the PMOP group were significantly higher than those in the N-PMOP group(P<0.05). In addition, HDL-C of patients in the PMOP group was significantly lower than that in the N-PMOP group(P<0.05). DBP, FPG, HDL-C and HCY of patients in the PMOP group were significantly lower than those in the MS-PMOP group(P<0.05). Logistic regression analysis showed an increase in SBP and FPG and a reduction of HDL-C were risk factors for PMOP. Conclusion Abnormal lipid metabolism and increased HCY may affect bone metabolism in postmenopausal women and increase the risk of PMOP. In addition, the increase in SBP and FPG, and the reduction of HDL-C are risk factors for PMOP. As agglomerates of various metabolic abnormalities, MS patients are at high risk for PMOP.
作者
尹肖寒
张宁
杨芳
张瑞岩
韩军
王正平
YIN Xiaohan;ZHANG Ning;YANG Fang;ZHANG Ruiyan;HAN Jun;WANG Zhengping(Institute of Biopharmaceutical Research,Liaocheng University,Liaocheng 252000;Clinical Nutrition Laboratory,Liaocheng People's Hosp让al,Liaocheng 252002,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2019年第10期1414-1418,1424,共6页
Chinese Journal of Osteoporosis
基金
山东省抗体制药协同创新中心开放课题(CIC-AD1839,CIC-AD1834)
山东省重点研发计划(2018YYSP008)
高稳定性肿瘤肠内全营养乳剂制备关键技术研究
关键词
绝经后骨质疏松症
脂代谢
代谢综合征
骨密度
postmenopausal osteoporosis
lipid metabolism
metabolic syndrome
bone mineral density
