摘要
合成了2种含氮类大豆苷元衍生物,4,7-二((甘氨酸钠)羰基)甲氧基异黄酮(L1)和4′,7-二(肼羰基)甲氧基异黄酮(L2)并用元素分析、红外光谱和核磁共振氢谱对其进行了表征。研究了大豆苷元衍生物的抗氧化性能,评价了其对自由基、超氧阴离子自由基的吸附能力,以及对人体血红细胞抗氧化损伤的保护作用。实验结果表明,大豆苷元衍生物在生理pH条件下的抗氧化活性优于维生素C,特别是在清除羟自由基和抑制人血红细胞溶血方面,大豆苷元衍生物抗氧化能力表现更为突出。大豆苷元衍生物的羟自由基清除活性IC50值是维生素C的104倍。
Two new daidzein derivatives containing nitrogen, 4′,7-bis(((sodium glycinate)carbonyl)methoxy) isoflavone (L1) and 4′,7-bis((hydrazinocarbonyl) methoxy) isoflavone (L2), have been synthesized and characterized by elemental analysis, IR and 1H NMR. The antioxidant properties of the daidzein derivatives were studied by evaluating its ability to capture the hydroxyl free radical, the superoxide anion free radical, and to protect erythrocytes of human blood against oxidative damage induced from AAPH (2,2′-azobis(2-amidinopropane) hydrochloride). Results of the experiments suggest that the daidzein derivatives show excellent antioxidant activity in physiological pH condition compared with vitamin C. Especially in the hydroxyl radical scavenging activity and suppressing the hemolysis of erythrocytes of human blood, the antioxidant capacity of the daidzein derivatives is more outstanding. The IC50 values of the daidzein derivatives were in the range of 0.1~1 μmol·L-1 on hydroxyl free radical scavenging activity, which was 104 times higher than that of vitamin C.
作者
刘会青
于渼璇
宋静磊
延玺
徐宁
郝海军
LIU Hui-Qing;YU Mei-Xuan;SONG Jing-Lei;YAN Xi;XU Ning;HAO Hai-Jun(College of Chemistry, Beijing Normal University, Beijing 100875, China;Department of Rheumatology and Immunology, Third Hospital of Peking University, Beijing 100083, China;Department of Organic Chemistry, College of Science, Beijing University of Chemical Technology, Beijing 100029, China)
出处
《无机化学学报》
SCIE
CAS
CSCD
北大核心
2019年第11期2168-2176,共9页
Chinese Journal of Inorganic Chemistry
基金
supported by Key Discipline Foundation of City of Beijing (Grant No.102-403101)~~
