摘要
重组人粒细胞刺激因子(recombinant human granulocyte colony-stimulating factor,rhG-CSF)能够促进髓系造血干细胞生成并分化为成熟中性粒细胞,可明显缩短骨髓抑制期,减少感染风险。其不良反应少见,但部分患者可能出现严重过敏反应,甚至低血压休克,过敏反应产生的机制目前并不完全清楚。保定市第一医院收治了1例对G-CSF出现严重不良反应,但仍需继续应用的白血病患者,经过一系列对症处理后患者病情稳定,最终达到骨髓部分缓解。
Recombinant human granulocyte colony-stimulating factor (rhG-CSF) can promote the generation and differentiation of myeloid hematopoietic stem cells into mature neutrophils, significantly shorten duration of bone marrow suppression and reduce the risk of infection. Its adverse reactions are rare, but some patients may have serious allergic reactions, even hypotensive shock. The mechanism of anaphylaxis is not completely clear at present. Baoding First Hospital admitted a patient with leukemia who had serious adverse reactions to G-CSF, but still needed to continue to use it. After a series of symptomatic treatment, the patient's condition was stable, and eventually achieved partial remission of bone marrow.
作者
王丽莉
齐林
王亚丽
吴娜
王凤云
成志勇
王素云
WANG Lili;QI Lin;WANG Yali;WU Na;WANG Fengyun;CHENG Zhiyong;WANG Suyun(Department of Emergency, Dingzhou People’s Hospital, Dingzhou Hebei 073000;Graduate School, Chengde Medical University, Chengde Hebei 067000;Department of Hematology, Baoding No.1 Hospital, Baoding Hebei 071000;Department of Hematology, Dingzhou People’s Hospital, Dingzhou Hebei 073000;Department of Hematology, Central Hospital of Longhua District, Shenzhen Guangdong 511000, China)
出处
《临床与病理杂志》
2019年第10期2338-2340,共3页
Journal of Clinical and Pathological Research
关键词
重组人粒细胞刺激因子
不良反应
白血病
化疗
recombinant human granulocyte colony-stimulating factor
adverse reaction
leukemia
chemotherapy
