摘要
目的探讨孕期亚临床甲状腺功能减退与妊娠期糖尿病的相关性。方法选取2016年2月至2018年10月于枣庄市妇幼保健院接受孕检的妊娠期糖尿病高危风险孕妇187例,均给予口服葡萄糖耐糖试验,结果显示正常耐糖者142例(NGT组),妊娠期糖尿病者45例(GDM组),另选取同期接受孕检的正常孕妇20例(对照组)。回顾分析三组孕妇的临床资料,比较其甲状腺功能、甲状腺自身抗体等指标。结果GDM组孕妇游离甲状腺素值低于NGT组、对照组,差异有统计学意义(t=13.427、23.901,P=0.000、0.000)。GDM组孕妇甲状腺过氧化物酶抗体值为(38.67±6.13)U/ml,高于NGT组孕妇[(30.09±5.26)U/ml]、对照组孕妇[(22.31±4.51)U/ml],差异有统计学意义(t=9.153、10.698,P=0.000、0.000);GDM组孕妇甲状腺自身抗体阳性率高于NGT组孕妇与对照组孕妇,差异有统计学意义(χ^2=18.538、3.369,P=0.000、0.031)。GDM组孕妇中亚临床甲状腺功能减退率为33.33%(15/45),高于NGT组[9.86%(14/142)]、对照组[5.00%(1/20)],差异有统计学意义(χ^2=14.370、4.561,P=0.000、0.014)。结论亚临床甲状腺功能减退与妊娠期糖尿病可相互影响,妊娠期糖尿病可对孕妇甲状腺功能造成损害,且易增加亚临床甲状腺功能减退率。
Objective To investigate the relationship between subclinical hypothyroidism and gestational diabetes during pregnancy. Methods A total of 187 pregnant women with high risk of gestational diabetes from February 2016 to October 2018 in Zaozhuang Maternal and Child Health Hospital were selected. All patients were given oral glucose tolerance test. The results showed that 142 cases of normal sugar tolerance (NGT group), pregnancy 45 patients with diabetes (GDM group). Another 20 normal pregnant women who received pregnancy test were allocated into control group. The clinical data of three groups were retrospectively analyzed, and their thyroid function and thyroid autoantibodies were compared. Results The free thyroxine levels in the GDM group were lower than those in the NGT group and the control group, and the differences were significant (t=13.427, 23.901, P=0.000, 0.000). The thyroid peroxidase antibody value of pregnant women in the GDM group was (38.67±6.13) U/ml, which was higher than that of the pregnant women (30.09±5.26) U/ml and NGT group (22.31±4.51) U/ml, and the differences were significant (t=9.153, 10.698;P=0.000, 0.000). The positive rate of thyroid autoantibodies in pregnant women in GDM group were higher than those in NGT group and control group (χ^2=18.538, 3.369;P=0.000, 0.031). The rate of subclinical hypothyroidism in pregnant women in the GDM group was 33.33%(15/45), which was higher than 9.86%(14/142) in the NGT group and 5.00%(1/20) in the control group. The difference among the three groups was significant (χ^2=14.370, 4.561;P=0.000, 0.014).Conclusions Subclinical hypothyroidism and gestational diabetes can affect each other. Gestational diabetes can impair thyroid function in pregnant women and increase the probability of subclinical hypothyroidism.
作者
房丽
Fang Li(Department of Obstetrics,Zaozhuang Maternal and Child Health Hospital,Zaozhuang 277100,China)
出处
《中国实用医刊》
2019年第18期71-73,共3页
Chinese Journal of Practical Medicine
