摘要
目的探讨右美托咪定与芬太尼联合丙泊酚在无痛人流术中的应用效果及对血流动力学、镇静程度和安全性的影响。方法选取2016年4月至2017年8月盘锦辽油宝石花医院诊治的施行无痛人流术治疗的86例患者为研究对象,将其随机分为观察组和对照组,每组43例患者。观察组患者联合使用右美托咪定+枸橼酸芬太尼+丙泊酚镇静治疗;对照组患者采用静脉泵注枸橼酸芬太尼联合丙泊酚镇静治疗。治疗后,观察两组患者手术后5min、10min、15min的Ramsay镇静评分和两组患者注射丙泊酚前(T0)、注射丙泊酚后(T1)、苏醒时(T2)3个时间点的平均动脉压(MAP)和心率(HR)、术中脑电双频指数(BIS)等数值情况,记录其手术时间和苏醒质量、丙泊酚用量和不良反应。结果观察组患者的丙泊酚用量低于对照组患者,药物起效时间短于对照组患者,其差异均具有统计学意义(均P<0.05);观察组患者手术时间为(5.67±1.39)min、术后苏醒时间为(7.84±2.31)min,对照组手术时间为(6.02±1.61)min、苏醒时间为(8.12±2.40)min,两者差异均无统计学意义(均P>0.05);T0时,观察组患者HR(83.04±12.42)次/min、MAP为(89.70±10.69)mmHg、BIS3(54.22±4.57)分,对照组患者HR(82.91±13.10)次/min、MAP(90.22±9.90)mmHg、BIS3(54.03±6.15)分,两组差异均无统计学意义(均P>0.05);T1时,观察组患者HR(82.85±11.90)次/min、MAP(88.67±9.90)mmHg,对照组患者HR(82.62±12.71)次/min、MAP(89.10±9.21)mmHg,观察组患者HR、MAP均优于对照组患者,其差异均具有统计学意义(均P<0.05);T2时,观察组患者HR(76.80±10.21)次/min、MAP(82.03±9.68)mmHg,对照组患者HR(77.08±10.26)次/min、MAP(82.12±9.30)mmHg;观察组患者HR、MAP水平均优于对照组患者,其差异均具有统计学意义(均P<0.05);观察组患者T0、T1、T2时段的BIS值依次为(54.22±4.57)、(86.13±6.28)和(90.45±8.03),对照组患者依次为(54.03±6.15)、(88.20±7.24)和(89.17±7.16),两者差异均无统计�
Objective To investigate the effects of dexmedetomidine and fentanyl combined with propofol on the hemodynamics, sedation and safety in painless induced abortion. Methods 86 patients who underwent painless abortion from April 2016 to August 2017 in our hospital were randomly divided into observation group and control group, with 43 patients in each group. Patients in the observation group were treated with dexmedetomidine and fentanyl citrate combined with propofol sedation;patients in the control group were treated with intravenous fentanyl citrate and propofol. After treatment, the Ramsay sedation scores of the two groups were observed at 5 min, 10 min, and 15 min after surgery, and the mean arterial pressure(MAP) and heart rate(HR), intraoperative bispectral index(BIS) before propofol injection(T0), after propofol injection(T1), and awake(T2) and other numerical conditions, the operation time and recovery quality, propofol dosage and adverse reactions were recorded. Results The amount of propofol in the observation group was lower than that in the control group, and the onset time of the drug was shorter than that in the control group, all with statistically significant differences(all P<0.05). The operation time and postoperative recovery time of the observation group was(5.67±1.39) min and(7.84±2.31) min, while those in the control group was(6.02±1.61) min and(8.12±2.40) min respectively, without statistically significant differences between the two groups(all P>0.05). At T0, the HR, MAP and BIS3 in the observation group was(83.04±12.42) times/min,(89.70±10.69) mmHg and(54.22±4.57) points respectively, and those in the control group was(82.91±13.10) times/min,(90.22±9.90) mmHg and BIS3(54.03±6.15) points accordingly, without statistically significant differences between the two groups(all P>0.05). At T1, the HR and MAP in the observation group was(82.85±11.90) times/min and(88.67±9.90) HRHg, while those in the control group was(82.62±12.71) times/min and(89.10±9.21) mmHg respectively, with stat
作者
寇广海
KOU Guanghai(Department of Operative Anesthesiology, Maternal and Infant Hospital, Panjin Liaoyou Gemstone Flower Hospital, Panjin 124010, Liaoning, China)
出处
《中国性科学》
2019年第10期66-70,共5页
Chinese Journal of Human Sexuality
