摘要
目的探讨不同剂量甲硝唑栓剂与克林霉素联用治疗老年性阴道炎的临床效果与安全性。方法选取2015年1月至2017年10月深圳市龙岗区第六人民医院诊治的180例老年性阴道炎患者作为研究对象。采用随机数字法分为A组(48例)、B组(50例)、C组(55例)和D组(55例)。A组患者给予中剂量甲硝唑栓剂,B组患者给予低剂量甲硝唑栓剂+克林霉素,C组患者给予中剂量甲硝唑栓剂+克林霉素,D组患者给予高剂量甲硝唑栓剂+克林霉素,比较各组患者的临床治疗效果及不良反应的发生率,并采用酶联免疫吸附测定法测定治疗前后血清内的雌二醇(estradiol,E2)和促卵泡激素(follicle stimulating hormone,FSH)的水平。结果与A组和B组相比,C组和D组患者的临床治疗总有效率均显著升高,差异具有统计学意义(P<0.05);治疗前,四组患者的E2和FSH水平相比,差异均无统计学意义(P>0.05),经治疗后,与A组、B组和C组相比,D组患者的E2水平显著降低,而FSH水平显著升高,差异具有统计学意义(P<0.05);四组患者在恶心、呕吐、头痛及腹泻等不良反应方面相比较,差异均无统计学意义(均P>0.05)。结论高剂量甲硝唑栓剂联合克林霉素治疗老年性阴道炎的临床效果较好,可显著改善机体的雌激素水平,且安全性较高。
Objective To investigate the clinical effect and safety of different dose metronidazole suppository combined with clindamycin in the treatment of senile vaginitis. Methods 180 patients with senile vaginitis treated in our hospital from January 2015 to October 2017 were selected and randomly divided into group A(48 cases), group B(50 cases), group C(55 cases) and group D(55 cases). Group A was given middle dose metronidazole suppository;group B was given low dose metronidazole suppository and clindamycin;group C was given middle dose metronidazole suppository and clindamycin;group D was given high dose metronidazole suppository and clindamycin. The clinical treatment effect and the incidence of adverse reaction were compared, and the levels of estradiol(E2) and follicle stimulating hormone(FSH) were tested by enzyme-linked immuno sorbent assay(ELISA). Results Compared with group A and group B, the total effective rate in group C and group D was significantly increased, with statistically significant differences(P<0.05). Before treatment, there was no statistically significant differences in the levels of E2 and FSH(P>0.05). After treatment, compared with group A, B and C, the level of E2 in group D was significantly decreased, but the FSH level significantly increased, with statistically significant differences(P<0.05). There were no statistically significant differences in the incidences of adverse reactions such nausea, vomiting, headache and diarrhea among the four groups(all P>0.05). Conclusions High dose metronidazole suppository combined with clindamycin is safe and effective in the treatment of senile vaginitis, which can significantly improve the level of estrogen.
作者
周艮春
HOU Genchun(Department of Gynaecology, Shenzhen Longgang District Sixth People′s Hospital, Shenzhen 518117, Guangdong, China)
出处
《中国性科学》
2019年第10期46-48,共3页
Chinese Journal of Human Sexuality
关键词
甲硝唑
克林霉素
老年
阴道炎
Metronidazole
Clindamycin
Senium
Vaginitis
