摘要
目的调查急性冠状动脉综合征(ACS)患者出院6个月内二级预防用药情况,并分析其相关影响因素。方法随机选取医院就诊的ACS患者140例,根据服用ACS二级预防用药推荐的4类药物的依从性高低分为依从性高组(97例)和依从性低组(43例),于出院6个月内以调查问卷的方式随访,对治疗效果(心痛次数及二次住院次数)、用药情况及医生开药情况进行统计。参照ACS的高危因素,并结合社会人口学资料分析影响ACS患者用药依从性的因素。结果依从性高组患者的心痛发作发生率及二次住院发生率均显著低于依从性低组(P <0. 05)。抗血小板类及调血脂类药物两组服用率均较高,且无显著性差异(P> 0. 05);β受体阻滞剂及血管紧张素转换酶抑制剂(ACEI)/血管紧张素Ⅱ受体拮抗剂(ARB)服用率较低,依从性高组服用率高于依从性低组,差异有统计学意义(P <0. 05);抗血小板类药物及调血脂类药物均有较高的开药率,且无显著性差异(P> 0. 05);β受体阻滞剂及ACEI/ARB的开药率随患者出院时间的增长而降低,差异有统计学意义(P <0. 05);年龄、经济收入、文化程度、病程、既往经皮冠状动脉介入治疗(PCI)史、发生药品不良反应及医护关系均为影响ACS患者二级预防用药的主要因素。结论 ACS患者出院6个月内主要服用抗血小板类药物、调血脂类药物。ACS患者二级预防用药受年龄、经济收入、文化程度、病程、既往PCI史、药品不良反应及医护关系等多重因素影响。
Objective To investigate the medication situation of secondary prophylactic drugs in patients with acute coronary syndrome( ACS) within six months after discharge,and to analyze the related influencing factors. Methods Totally 140 patients with ACS treated in our hospital were selected and divided into the high-compliance group( n = 97) and the low-compliance group( n = 43) according to the compliance of taking four kinds of recommended secondary prophylactic drugs for ACS. The patients were followed up by questionnaires within 6 months after discharge. The therapeutic effect( the times of heartache and the times of secondary hospitalization),the medication situation of patients and the doctor’s prescribing condition were analyzed. According to the high-risk factors of ACS and the sociodemographic data of patients,the factors affecting the medication compliance of patients with ACS were analyzed. Results The incidence of heartache and secondary hospitalization in the high-compliance group were significantly lower than those in the low-compliance group( P < 0. 05). The rates of taking antiplatelet drugs and lipid-regulating drugs in both groups were high without significant difference( P > 0. 05). The rates of taking β-blocker drugs and angiotensin-converting enzyme inhibitor( ACEI)/angiotensin Ⅱ receptor blocker( ARB) drugs were lower,and the taking rates in the high-compliance group were significantly higher than those in the low-compliance group( P < 0. 05). The prescription rates of antiplatelet drugs and lipid-regulating drugs were high,and there was no significant difference between the two groups( P > 0. 05). The prescription rates of β-blocker and ACEI/ARB drugs decreased with the increase of discharge time,and the difference was statistically significant( P < 0. 05). The age,income,education,course of disease,history of percutaneous coronary intervention( PCI),adverse drug reactions and medical-nursing relationship were the main factors affected secondary prophylactic drug use in patients with ACS.
作者
范良伟
刘涛
刘宗涛
FAN Liangwei;LIU Tao;LIU Zongtao(Community Center of Wuhan Red Cross Hospital,Wuhan,Hubei,China 430015)
出处
《中国药业》
CAS
2019年第21期71-73,共3页
China Pharmaceuticals
基金
湖北省科技计划项目[2014CFB334]
关键词
急性冠状动脉综合征
二级预防
用药现状
依从性
影响因素
acute coronary syndrome
secondary prevention
medication situation
compliance
influencing factors
