摘要
血液传播性病原体可引起输血传播性疾病。采供血机构对血液传播性病原体检测能力的高低与血液安全水平密切相关,阐明献血者血液传播性病原体的宏基因组学,有助于制定输血传播性疾病的防治策略,提升血液安全。笔者拟就基于高通量测序的血液传播性病原体宏基因组检测技术及其基本流程、献血者血液传播性病原体宏基因组检测情况进行介绍,并且对血液传播性病原体宏基因组检测技术的发展进行展望。
Blood borne pathogens can cause transfusion transmitted diseases. The detection ability of blood borne pathogens in blood services is closely related to the level of blood safety. To explore the metagenomics of blood borne pathogens in blood donors is helpful to formulate corresponding prevention strategies for transfusion transmitted diseases and to improve blood safety. This article reviews the techniques and basic procedures of metagenome detection of blood borne pathogens, as well as the metagenome data in blood donors. The development of detection techniques in the blood borne pathogens metagenome is also prospected.
作者
戴潇青
徐罡
胡伟
朱发明
Dai Xiaoqing;Xu Gang;Hu Wei;Zhu Faming(Blood Center of Zhejiang Province, Key Laboratory of Blood Safety Research in Zhejiang Province, Hangzhou 310052, Zhejiang Province, China)
出处
《国际输血及血液学杂志》
CAS
2019年第5期369-373,共5页
International Journal of Blood Transfusion and Hematology
基金
科技部重点研发计划(2018YFC2000500)
国家卫生健康委员会科学研究基金(WKJ-ZJ-1815)
浙江省医药卫生科技计划项目(2017KY316).
