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对氧磷酶-1Q192R基因多态性与氯吡格雷治疗冠心病疗效之间相关性的研究进展 被引量:3

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摘要 氯吡格雷是冠心病的一线治疗药物,广泛应用于临床。然而,在临床实践中,氯吡格雷疗效存在明显的个体差异性,一些患者因为治疗反应差而出现再次缺血事件。氯吡格雷的疗效受到多种因素的影响,其中药物基因多态性是影响氯吡格雷疗效的主要因素之一。国内外大量研究报道了对氧磷酶-1Q192R(PON-1Q192R)基因多态性对氯吡格雷治疗冠心病的影响。本文对PON-1Q192R基因多态性与氯吡格雷治疗冠心病疗效之间的相关性进行综述,为临床制定个体化治疗方案提供参考。
作者 邓树强
出处 《牡丹江医学院学报》 2019年第5期106-109,共4页 Journal of Mudanjiang Medical University
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