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尖刀唇石斛化学成分研究 被引量:8

Chemical constituents from Dendrobium heterocarpum Lindl.
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摘要 本文对尖刀唇石斛(Dendrobium heterocarpum Lindl.)中的化学成分及其抗炎和抗氧化活性进行研究。实验采用硅胶、Sephadex LH-20凝胶和高效液相色谱等手段进行分离纯化,并用波谱学方法鉴定化合物结构,从尖刀唇石斛的乙酸乙酯萃取部位中分离得到15个化合物,分别鉴定为3,4′-二羟基-5-甲氧基联苄(1)、batatasinⅢ(2)、3-羟基-4′,5-二甲氧基联苄(3)、3-O-methylgigantol(4)、gigantol(5)、3,4-二羟基-4′,5-二甲氧基联苄(6)、moscatilin(7)、dendrocandin A(8)、(S)-3,4,α-三羟基-4′,5-二甲氧基联苄(9)、densiflorol A(10)、dendrocandin I(11)、dendrocandin F(12)、coelonin(13)、红花素(14)、4-羟基-2-甲氧基-3,6-二甲基苯甲酸(15)。化合物1~15均为首次从该种植物中分离得到,其中化合物14为首次从该属植物中分离得到。化合物3、5、11具有抑制小鼠RAW264.7巨噬细胞生成一氧化氮的作用;化合物5具有较好的ABTS自由基清除能力,化合物6具有较好的DPPH自由基清除能力。 The aim of this research was to investigate the chemical constituents from Dendrobium heterocarpum Lindl.and antioxidant and anti-inflammatory activities of selected compounds.15 compounds were isolated and purified from Dendrobium heterocarpum Lindl.by silica gel column chromatography,Sephadex LH-20 and semipreparative HPLC.And their structures were identified as 3,4′-dihydroxy-5-methoxybibenzyl(1),batatasinⅢ(2),3-hydroxy-4′,5-dimethoxybibenzyl(3),3-O-methylgigantol(4),gigantol(5),3,4-dihydroxy-4′,5-dimethoxybibenzyl(6),moscatilin(7),dendrocandin A(8),(S)-3,4,α-trihydroxy-4′,5-dimethoxybibenzyl(9),densiflorol A(10),dendrocandin I(11),dendrocandin F(12),coelonin(13),carthamidin(14),4-hydroxy-2-methoxy-3,6-dimethylbenzoic acid(15)based on extensive spectroscopic methods 1H NMR,13 C NMR,HSQC,HMBC).Compounds 1-15 were isolated from Dendrobium heterocarpum for the first time,of which compound 14 were obtained from this genus for the first time.Some isolates were evaluated for the inhibitory activities on nitric oxide production and the ABTS and DPPH radical scavenging activity.Compounds 3,5 and 11 showed inhibitory effect on the NO production in RAW264.7 macrophage cell.And Compounds 5 and 6 showed DPPH and ABTS+radicals scavenging activity.
作者 杨晓蓓 颜莎 胡江苗 周俊 YANG Xiao-bei;YAN Sha;HU Jiang-miao;ZHOU Jun(State Key Laboratory of Phytochemistry and plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China;University of Chinese Academy of Science,Beijing 100049,China)
出处 《天然产物研究与开发》 CAS CSCD 北大核心 2019年第10期1745-1752,共8页 Natural Product Research and Development
基金 云南石斛产业转型升级技术研究与产业化(2017ZF003-04)
关键词 尖刀唇石斛 联苄 红花素 RAW264.7巨噬细胞 DPPH自由基 Dendrobium heterocarpum bibenzyl carthamidinl RAW264.7 macrophage cell DPPH radical
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