摘要
Beclin-1作为重要的自噬调节因子在肿瘤发生和进展过程中起到重要作用。然而近年来越多越多的研究揭示,除调控自噬外,Beclin-1还可通过非自噬依赖性通路调控生长因子受体信号通路、协助细胞有丝分裂、促进DNA损伤修复以及间接促进肿瘤细胞凋亡进程,进而影响肿瘤发生和进展。该文将对Beclin-1在肿瘤中的非自噬依赖性功能进行综述。
As an important regulator of autophagy,Beclin-1 plays a crucial role in tumor initiation and progression.However,an increasing number of studies have revealed that,in addition to regulating autophagy,Beclin-1 could also influence tumorigenesis and progression via regulating growth factor receptor signaling,assisting mitosis,promoting DNA damage repair and indirectly increasing cell apoptosis which are autophagy-independent.This review summarizes the autophagy-independent roles of Beclin-1 in tumors.
作者
应杰
王梦
张蒙
梁朝朝
YING Jie;WANG Meng;ZHANG Meng;LIANG Chao-Zhao(Department of Urology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China;Department of Urology,Luohu Hospital of Shenzhen University,Shenzhen 518000,China)
出处
《生命科学》
CSCD
北大核心
2019年第8期795-801,共7页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金青年基金项目(81802827)
广东省自然科学基金目(2017A030313800)
