摘要
目的探讨中药熏洗治疗结核性胸膜增厚的临床疗效.方法选择2017年1~12月在我院诊断治疗的结核性胸膜增厚患者80例为研究对象,随机分为干预组与对照组,每组40例.对照组采用常规抗结核治疗,干预组在对照组基础上加用中药熏洗治疗.分别于治疗前、治疗后2周、8周采用B超检查胸膜厚度变化;比较两组患者临床疗效;分别于治疗前及治疗1周后检测胸腔积液中肿瘤坏死因子(TNF-α)、纤维蛋白原(FIB)、转化生长因子(TGF-β1)水平变化.结果干预组总有效率(100.0%)显著高于对照组(82.5%),差异有统计学意义(P<0.05);治疗1周后,两组患者胸腔积液中TNF-α、FIB及TGF-β 1水平较治疗前均显著下降,差异有统计学意义(P<0.05),且治疗1周后,干预组胸腔积液中TNF-α、FIB及TGF-β 1水平显著低于对照组,差异有统计学意义(P<0.05);治疗后2周、8周,两组胸膜厚度均较治疗前显著下降,差异有统计学意义(P<0.05),且治疗后2周、8周,干预组患者胸膜厚度均显著低于对照组,差异有统计学意义(P<0.05).结论中药熏洗治疗结核性胸膜增厚具有较好的临床疗效,值得临床推广应用.
Objective To explore the therapeutic effect of traditional Chinese medicine fumigation and washing on tuberculous pleural thickening. Methods A total of 80 patients with tuberculous pleural thickening treated in our hospital from January to December 2017 were selected and randomly divided into intervention group and control group, with 40 patients in each group. The patients in the control group were given routine antituberculosis therapy, and those in the intervention group were additionally given traditional Chinese medicine fumigation and washing therapy. The thickness of pleura were examined by B-ultrasound before treatment, 2 weeks and 8 weeks after treatment. The treatment effects were compared between the two groups. Tumor necrosis factor(TNF-α), fibrin level(FIB), and transforming growth factor (TGF-β1) were measured in pleural effusion before treatment and 1 week after treatment. Results The total effective rate of the intervention group (100.0%) was significantly higher than that of the control group (82.5%), and the difference was statistically significant(P<0.05). After 1 week of treatment, the levels of TNF-α, FIB and TGF-β1 in pleural effusion in both groups were significantly lower than those before treatment (P<0.05). After 1 week of treatment, the levels of TNF-α, FIB and TGF-β1 in the intervention group were significantly lower than those in the control group(P<0.05). At 2 weeks and 8 weeks after treatment, the pleural thickness of the two groups was significantly thinner than that before treatment (P<0.05). The pleural thickness of the intervention group was significantly thinner than that of the control group at 2 weeks and 8 weeks after treatment, and the difference was statistically significant(P<0.05). Conclusion Traditional Chinese medicine fumigation and washing has good effect on tuberculous pleural thickening, which is worthy popularizing application in clinic.
作者
洪菲
崔岩飞
HONG Fei;CUI Yanfei(Department of Tuberculosis,Hangzhou Red Cross Hospital,Hangzhou 310003,China)
出处
《中国现代医生》
2019年第26期136-139,共4页
China Modern Doctor
基金
浙江省中医药科技计划项目（2016ZB098）
关键词
中药熏洗
结核
胸膜增厚
肿瘤坏死因子
纤维蛋白原
转化生长因子
Traditional Chinese medicine fumigation and washing
Tuberculosis
Pleural thickening
TNF-α
FIB
TGF-β1
