摘要
目的探讨尼莫地平治疗创伤性蛛网膜下腔出血的疗效。方法收集2016年1月~2018年12月期间在我院治疗的创伤性蛛网膜下腔出血患者76例,使用随机抽签的方法分为实验组和对照组,各38例,对照组使用常规治疗,实验组在对照组基础上使用尼莫地平进行治疗,对两组患者的Vp值、GCS评分及治疗总有效率进行统计和分析。结果两组入院后不同时间段伤侧大脑中动脉的收缩峰流速比较,入院时(t=1.360,P=0.089)、入院后第3天(t=1.223,P=0.252)、5 d(t=2.112,P=0.100)无统计学意义,实验组的Vp值较对照组7 d(t=3.989,P=0.001)、14 d(t=4.359,P=0.002)、21 d(t=4.472,P=0.001)显著下降;GCS的评分变化情况在入院时(t=1.545,P=0.072)、入院后第3天(t=1.112,P=0.094)、5 d(t=1.859,P=0.080)无统计学意义,实验组第7天(t=3.949,P=0.001)、14 d(t=4.610,P=0.002)、21 d(t=4.582,P=0.002)上升趋势明显优于对照组,且组间、不同时间段及组间与不同时间点交互作用均有统计学意义(P<0.05),且实验组对于创伤性蛛网膜下腔出血的治疗总有效率明显优于对照组。结论尼莫地平对于创伤性蛛网膜下腔出血的患者疗效显著,实验组患者在治疗及随访过程中未发现使用药物所产生不良反应,患者近远期康复情况理想,可有效改善患者预后,降低致残率,大大提升此类患者的生存率。
Objective To investigate the therapeutic effect of nimodipine in the treatment of traumatic subarachnoid hemorrhage. Methods A total of 76 patients with traumatic subarachnoid hemorrhage who were treated in our hospital from January 2016 to December 2018 were collected. The patients were divided into experimental group and control group according to the random draw lots, with 38 cases in each group. The experimental group was treated with nimodipine on the basis of the control group, and the control group was given conventional treatment. The Vp value, GCS score and total effective rate were statistically analyzed in both groups. Results The systolic peak flow velocity of the middle cerebral artery in the injured side at different time points after admission were compared between the two groups: upon admission(t=1.360, P=0.089), 3 days after admission (t=1.223, P=0.252), and 5 days after admission (t=2.112, P=0.100). The differences were not statistically significant. The Vp value in the experimental group was significantly lower than that in the control group for 7 days (t=3.989, P=0.001), 14 days (t=4.359, P=0.002), and 21 days (t=4.472, P=0.001);changes of GCS scores were not statistically significant upon admission(t=1.545, P=0.072), 3 days after admission(t=1.112, P=0.094), and 5 days after admission (t=1.859, P=0.080). The increases in the experimental group on 7 days (t=3.949, P=0.001), 14 days(t=4.610, P=0.002), and 21 days (t=4.582, P=0.002) were significantly greater than those in the control group. The interactions between groups and during different time periods, and between groups and at different time points were statistically significant (P<0.05), and the total therapeutic effective rate of traumatic subarachnoid hemorrhage in the experimental group was significantly better than that in the control group. Conclusion Nimodipine is effective in the patients with traumatic subarachnoid hemorrhage. In the experimental group, no drug-related adverse reactions were observed during the treatment and follo
作者
朱子煜
ZHU Ziyu(Department of Neurosurgery,Jiamusi Central Hospital in Heilongjiang Province,Jiamusi 154002,China)
出处
《中国现代医生》
2019年第27期29-32,共4页
China Modern Doctor
