摘要
目的:探讨磷酸化信号转导与转录因子3(p-signal transducers and activators of transcription3, p-STAT3)表达与肝癌临床病理特征间相关性。方法:收集2012年1月至2017年6月于我院行肝胆外科手术治疗并经病理证实为肝癌的80例患者肝癌组织及癌旁组织样本。免疫组织化学法检测肝癌组织及癌旁组织中p-STAT3的表达水平,并比较二者阳性表达率;同时分析p-STAT3表达与临床病理参数间的关系,以及不同p-STAT3表达水平患者间的生存率。结果:80例肿瘤组织中p-STAT3阳性表达率为67.5%(54/80)显著高于癌旁组织的22.5%(18/80),(P<0.05)。p-STAT3的表达与TNM分期及门静脉侵犯情况相关(P<0.05),而与患者的年龄、HBsAg感染情况、AFP水平、肿瘤数量及直径等无关(P>0.05)。以p-STAT3评分的中位数为节点,将患者分为高表达组和低表达组。高表达组的1、3年生存率分别为60.5%(23/38)、15.8%(6/38),低表达组的1、3年生存率分别为93.8%(15/16)、50.0%(8/16),组间比较低表达组的1、3年的生存率均高于高表达组(P<0.05)。结论:p-STAT3在肝癌组织中呈高表达,其表达水平与临床分期、门静脉系统侵犯情况相关, p-STAT3低表达患者术后生存率更高,可作为肝癌术后的预后评价指标。
Objective To investigate the correlation between the expression of p-signal transducers and activators of transcription 3(p-STAT3) and the clinicopathological features of liver cancer. Methods Liver cancer tissues and paracancerous tissues were collected from 80 patients with liver cancer who underwent hepatobiliary surgery and confirmed by pathology in our hospital from January 2012 to June 2017. The expression of p-STAT3 in hepatocarcinoma and paracancerous tissues was detected by immunohistochemistry, and the positive expression rates of the two were compared. The relationship between the expression of p-STAT3 and clinicopathological parameters was analyzed, and the survival rate among patients with different expression levels of p-STAT3 was also analyzed. Results The positive expression rate of p-STAT3 in the tumor tissues was 67.5%(54/80), which was significantly higher than that in the adjacent tissues(22.5%, 18/80)(P<0.05). The p-STAT3 expressions were correlated with the TNM stage and portal vein invasions(P<0.05), but not with age, HBsAg infection, AFP level, tumor number and diameter(P>0.05). The patients were divided into a high expression group and a low expression group by taking the median of the p-STAT3 score. The 1-and 3-year survival rates of the high-expression group were 60.5%(23/38) and 15.8%(6/38), respectively. The 1-to 3-year survival rates of the low-expression group were 93.8%(15/16) and 50. 0%(8/16), repectively. The 1-to 3-year survival rate of the lower-expression group was higher than that of the high-expression group(P<0.05). Conclusion P-STAT3 is highly expressed in the liver cancer tissues. Its expression level is correlated with the clinical stage and portal vein invasions. The survival rate of patients with low p-STAT3 expression is higher, which it can be considered as an evaluation index of clinical prognosis.
作者
程雄飞
喻雄杰
余建云
CHENG Xiong-fei;YU Xiong-jie;YU Jian-yun(Department of Oncology, Renmin Hospital, Hubei University of Medicine, Shiy an, Hubei 442000, China)
出处
《湖北医药学院学报》
CAS
2019年第4期361-363,368,共4页
Journal of Hubei University of Medicine
基金
十堰市科技局项目(17Y39)
