摘要
目的探讨供、受者性别因素对移植肾功能延迟恢复(delayed graft function,DGF)的影响及其原因.方法按纳入、排除标准严格筛选,回顾性分析武汉大学中南医院移植中心在2012年5月1日至2017年12月31日期间174例供者与265例肾移植受者临床资料,统计供者器官捐献类型、年龄、末次肌酐、身高、体重、身体质量指数(BMI)与原发病数据,同时统计受者术前透析方式、术前透析时间、HLA错配位点数、术后第7天肌酐、术后7 d内是否透析、年龄、身高、体重与BMI等资料,对计数资料进行t检验,计量资料进行卡方检验,P<0.05为差异有统计学意义.结果供者性别对受者肾移植术后DGF发生率无影响(P=0.689),但女性受者肾移植术后DGF发生率显著低于男性受者(P=0.036);女性供者原发病为脑出血较男性供者多(P=0.034).女性受者术前透析方式选择腹膜透析较男性受者多(P=0.023);女性受者BMI(P<0.001)、术后第7天肌酐(P=0.001)均低于男性受者.结论女性受者肾移植术后DGF发生率低于男性.
Objective To explore the effects of donor/recipients' gender on delayed graft function (DGF).Methods A retrospective analysis was performed for clinical data of donors (n=174) and recipients (n=265) during renal transplantation between May 1 ,2012 and December 31 ,2017 . Types of China donation after citizen's death ,age ,last creatinine level ,height ,weight ,body mass index (BMI) and protopathy of donors were collected .And pre-dialysis method ,dialysis time ,HLA mismatch ,post-creatine at Day 7 ,whether dialysis after transplantation ,height ,weight and BMI of recipients were analyzed .The data were checked by t and chi square tests and P<0 .05 was deemed as statistically significant .Results Donor gender had no correlation with DGF occurrence rate ( P=0 .689) while DGF occurrence rate among female recipients was evidently lower than that among males (P=0 .036);Female recipients selected peritoneal dialysis therapy more than male recipients (P=0 .023);Cerebral hemorrhage female donors were more than male donors (P= 0 .034);BMI (P<0 .001) and postoperative creatinine (P= 0 .001) among female recipients were evidently lower than that among males .Conclusions DGF occurrence rate is significantly lower among female receptors than that among males after kidney transplantation .
作者
周大为
梁峻滔
王彦峰
彭贵主
叶少军
夏志平
胡晓燕
叶啟发
Zhou Dawei;Liang Juntao;Wang Yanfeng;Peng Guizhu;Ye Shaojun;Xia Zhiping;Hu Xiaoyan;Ye Qifa(Zhongnan Hospital of Wuhan University,Institute of Hepatobiliary Diseases of Wuhan University,Transplant Center of Wuhan University,Hubei Key Laboratory of Medical Technology on Transplantation,Wuhan 430071,China)
出处
《中华器官移植杂志》
CAS
北大核心
2019年第7期414-418,共5页
Chinese Journal of Organ Transplantation
基金
国家自然科学基金新疆联合基金(U1403222)
湖北省卫生健康委员会联合基金(WJ2019H032/znpy2018065).
关键词
肾移植
性别
雌激素
Kidney transplantation
Gender
Estrogen
